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Pharmacology > Drug abuse > Flashcards

Drug abuse Flashcards

1
Q

Dependence

A

withdrawal syndrome- signs/symptoms which occur when a drug is no longer available, drugs of abuse, nonpsychoactive drugs

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2
Q

Addiction

A

compulsive, relapsing drug use despite neagative consequences, triggered by cravings and contextual cues

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3
Q

3 stages of dependence

A

chronic exposure- adaptation, tolerance- need for increased dose, withdrawal- changes apparent when drug is terminated

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4
Q

Dopamine hypothesis of addiction

A

physiologic condition- mesolimbic DA- learning and adaptation; addiction- mesolimbic dopamine- pleasure and rewards center, stimulus and rewards, result- behavior becomes compulsive

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5
Q

Caffeine pharmacology

A

CNS-stimulant, cardiac, resp, and diuretic effect; therapeutic- asthma, narcolepsy, HA, resp depression in neonatal pop*, behavior effects- increased mental alertness

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6
Q

Caffeine dosing

A

effects seen with small oral dose- 100-200mg, 1-2 cups coffee, lethal dose- 10 grams/ 100 cups coffee

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7
Q

Caffeinism

A

clinical syndrome- central and peripheral sx, CNS: anxiety, insomnia, mood changes, peripheral: tachycardia, HTN, arrhythmias, GI disturbances; generally dose related

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8
Q

Caffeine tolerance and dependence

A

chronic use associated w/ habituation/ tolerance, may produce low-grade withdrawal sx, HA, drowsiness, fatigue, neg mood state, maximaized after 1-2 days and cease withing few days

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9
Q

Nicotine pharmacology

A

selective agonist of nicotinic AcH receptor causing rewarding effect, effects= early- nausea/vomiting, stimulates hypothalamus to release antidiuretic hormone, reduce nerve fivers in muscle, reduce appetitie, alters taste buds, increases psychomotor activity, memory

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10
Q

Effects of nicotine on periphery

A

inc heart rate, blood pressure, cardiac contractility, vasodilates nom-atherosclerotic coronary arteries

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11
Q

Nicotine tolerance and dependence

A

clearly induces both physiological and psychological dependence, w/drawal syndrome is not life threatening

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12
Q

Nicotine toxicity

A

nicotine- responsible for acute pharm effects and withdrawal signs; tar- responsible for disease associated long term tobacco use, life is shortened by 14 mins for every cigarette smoked

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13
Q

Nicotine cardiovascular disease

A

CO- dec o2 delivery to heart muscle, nicotine- inc myocardial O2 demand d/t cardiac stimulation, both inc the incidence of atherosclerotic and thrombosis in coronary arteries, atherosclerosis also occurs elsewhere- strokes

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14
Q

Nicotine Pulmonary disease

A

smokers syndrome- diff breathing, wheezing, chest pain, lung congestion, inc susceptibility to RTI, impairs ventilitation, reduces immune effects of lungs

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15
Q

Nicotine Cancer

A

major cause of lung ca, mouth, laryngeal, throat, bladder, pancreatic, uterine, cervical

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16
Q

Nicotine pregnancy

A

adversely effects developiing fetus, low birth weight, preterm delivery, cig smoke reduces O2 delivery to developing fetus, cessation early in preg appears to reverse these effects

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17
Q

Approaches to smoking cessation

A

Gum, inhaler, lozenge, nasal spray, transdermal, drugs

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18
Q

Bupropion (Zyban)

A

antidepressant may mimic nicotinic effects on DA and norepinephrine, start 1-2 weeks prior to target wuit date, Day 1-3 150mg orally once daily, Day 4- 150 mg orally BID, continue 7-12 weeks

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19
Q

ADRs of bupropion

A

tachycardia, HA, insomnia, dizziness, wt loss, nausea, pharyngitis

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20
Q

Varenicline (Chantix)

A

a4B2 nAcHR partial agonist works on DA neurons of the VTA preventing nicotine from exerting action, start 1 week prior to quit date, day 1-3: .5 mg orally twice every day, D 4-7: .5 mg orally BID, Day >8: 1 mg orally BID for 11 weeks

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21
Q

ADRs of varenicline (Chantix)

A

HA, insomnia, abnormal dreams, suicidal ideation, angina

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22
Q

Cocaine Pharmacology

A

Inhibits DA tranporter- dec DA clearance from the synaptic cleft and causes an inc in extracellular DA concentration

23
Q

Cocaine effects of moderate-dose use

A

as duration inc, effects are intensified followed by depression, anxiety, somnolence, progressive loss of coordination followed by tremors and eventually seizures, local depletion of O2, vascular thrombosis, brain hemorrhage, cardiac complications

24
Q

Cocaine effects of long term- high dose

A

toxic paranoid psychosis, produces toxic sx- anxiety, sleep deprivation, hypervigilance, suspiciousness/ paranoia, interpersonal conflicts, depression, dysphoria, and bizarre violent psychotic disorders

25
Q

Comorbities and cocaine

A

typically effect young (12-39 yom), generally reckless, rebellious, low tolerance for frustration, may have coexisting anxiety, depression, paranoia, bipolar, antisocial personality, PTSD, ADHD

26
Q

Treatment of dependence of cocaine

A

cog- behavior therapy- contingency management strategies are usefule in preventing relapse, no FDA approved pharm therapy, disulfiram, suboxone, ritalin, wellbutrin, modafil (Provigil), gabapentin

27
Q

Amphetamines pharmacology

A

competitively inhibits DA transport causing inc in extracellular DA concentration, interferes w/ vesicular monamine transporter and impedes filling of synaptic vesicles (cytoplasmic release of DA)

28
Q

CNS and peripheral effects of amphetamines

A

tremor, restlessness, increased motor activity, agitation, insomnia, and loss of appetite, vasoconstricion, HTN, tachy

29
Q

Chronic high dose users of amphetamines

A

contiual, purposeless, repetitive acts, sudden outbursts of aggression and violence, paranoid delusions, psychosis and abnormal mental conditions and severe anorexia

30
Q

Amphetamines in pregnancy

A

may exhibit growth retardation and lower birth wt, inc incidence of intracerebral hemorrhage, evidence of psychometric deficits, poor academic performance, behavioral probs, cog slowing, and general maladjustment

31
Q

Dependence and tolerance of amphetamines

A

potent psychomotor stimulant and behavior-reinforcing agen prone to compulsive abuse, physical dependence follow positive cond model, withdrawal sx, paranoia, wt gain, inc appetitie, fatigue

32
Q

Treatment of amphetamine

A

d/c drug, cautious clin observation, recognize depression, treat w/ antidepressants, antipsychotic drugs- risperidone, quetiapine may be necessary

33
Q

Treatment of psychosis of amphetamine

A

primarily supportive, haloperidol, olanzapine, psychotic relapse following d/c were common over 30 months, hallucinations, delusions, depression, suicidal ideation

34
Q

Ethyl alcohol Pharmacology

A

alters GABA, Kir/GIRK, adenosine reuptake, glycine rec, NMDA, and 5HT3; reversible depr of behavior, mental functioning and cognition, resp is stimulated at low dose but dec w/ inc dose, CNS depression, high dose= heart disease

35
Q

Blood EtOH levels

A

.02 (g/dL)= dec inhibition, slight buzz; .08+ dec in complex cog function and motor performance; .2= obvious slurred speech, motor incoordination, irritability, poor judgement; .3= light coma and depressed vitals; .4=death

36
Q

Tolerance and dependence of EtOH

A

tolerance w/ reg use, metabolic tolerance- liver inc amt of drug metabolizing enzyme; tissue- neurons in brain adapt to amt present; association, contingent or homeostatic tolerance- environment manipulation can counter effects of etoh, counter response are possible mech of tolerance

37
Q

Withdrawal of EtOH

A

sweating, N/V, tremors, anxiety, agitation, paranoia, hallucinations, DT, seizures

38
Q

Stage 1 of EtOH withdrawal

A

6-8 hrs- tremors, anxiety, HA, GI upset, sweating

39
Q

Stage 2 of EtOH withdrawal

A

10-30 hrs- insomnia, hallucinations, autonomic hyperactivity

40
Q

Stage 3 of EtOH withdrawal

A

first 3 days- grand mall seizures

41
Q

Stage 4 of EtOH withdrawal

A

3-5 days- delirium tremors, agitation, hallucinations, tachy, HTN, fever, diaphoresis

42
Q

Pregnancy and EtOH

A

physical and behavioral teratogen, causes alterations in brain structure or function, FAS- development disorder in offspring of mothers w/ high BAL during critical stages of fetal development

43
Q

Effects of FAS

A

CNS dysfunction- low intelligence and microcephaly, mental retardation, behavioral abnormalities, dec growth rate, facial abnormalities, congenital heart defects and malformed eyes and ears

44
Q

Treatment of EtOH withdrawal

A

Benzos- inc GABA activity and ameliorate the sx, can prevent seizures and DT, lorazepam, diazepam, and chlordiazepoxide, multivitamins, thiamine, folic acid and fluids (banana bag), anticonvulsants

45
Q

Anticonvulsants for EtOH withdrawal

A

carbamazepine, valproic acid, gabapentin, pregabalin, oxcarbazepine, lamotrigine, topiramate

46
Q

Drugs to prevent EtOH relapse

A

Disulfiram (Antabuse), Naltrexone (revia)- opioid antagonist, acamprosate (Campral)- GABA agonist/glutamate antagonist

47
Q

Dose?ADRs of Disulfiram (Antabuse)

A

500 mg PO daily for 1-2 weeks, then 250 mg PO daily until recovered, cause drowsiness, HA fatigue, rash taste disturbance

48
Q

Naltrexone (revia) dose and ADRs

A

50 mg PO, syncope, HA, insomnia, N/V?D dec appetitie

49
Q

Acamprosate (Campral) dose and ADRs

A

666mg PO TID, diarrhea, ch pain, HTN, insomnia, anxiety

50
Q

Cannabinoids Pharm

A

binds to cannabinoid rec and inhibit release of glutamate or GABA, THC is active substance and is powerfully psychoactive

51
Q

Physiological affects of cannabinoids

A

analgesia, cog alterations, euphoria, dec body temp, calms aggression, blocks convulsants, inc HR, HTN, may contain more tars, bronchial irritation, inc lung CA

52
Q

Tolerance and dependence of Cannabinoids

A

down reg and desensitizationof brain cannabinoid receptors, behavioral tolerance, mild and short lived withdrawal syndrome, restlessness, irritability, agitation, anger, insomnia, strange dreams, nausea, depression

53
Q

Treatment of cannaminoid withdrawal

A

psychotherapeutic strategies- cog behavior therapy, contingency management, family counseling, motivational enhancement interventions, mertezepine (Remeron), dronabinol (Marinol), Bupropion, buspirone (Buspar), naltrexone (revia)

Pharmacology (61 decks)

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