SYMP - Rheumatoid Arthritis Flashcards
what is it
how does it change with tine
what is the goal of treatment
what are the characteristics of RA
who doers it effect
how does it effect body and what can this lead to
RA joint damage
hwo is it like and how does it present
what is synovitis exactly—pathophysiology
PA pathology
what is a pannus
what is the synovial fluid in RA rich in
what happens in RA as a result in this, what are they involved in??? what can this help used to measure
t cells and RA
how are they connected, what has been showed
which ones, what do they do???
b cells
how are they involbed and why
cartilage erosion
—how does this happen
what does this lead to
bone erosion
—how does this happen
clinical markers for RA
pto for more q abut them
rheumatoid factor – what is this what does it lead to. why is/isnt it useful
ccp Ab aka ACPA
what is this, pros / cons
citrullination
what is this, hpe is it linked to RA
do anti CCP Ab have a pathogenic role?
——what is possible mechanism
RA EITIOLOGY
polmorphims assoc with
genetics and twons
genetics of RA
hormones
for f and m – how related
smoking
what has been shown
infectious trigger for ra
studies? why or why not the case
treatment RA
what are the 2 main types and what do they do and some exapmples
0—-
anti inflam drugs – what are there and how do they work
how long to use and why
synthetic DMARDs
what are there
how work
exampes
how is it given and why
ADVERSE EFFECTS
new RA treatments
how do they work and what do they act on
what is it it called
what is licenced
give eg on back
tnf blockers
monoclonal ab against b cells
t cell co stim blocker
IL-6 blocker
infliximab
entanercept
adalimumab and golimubab
certolizumab pegol
what is it how does it work
anti-tnf therapy
what are some side effects and what needs to be considered
if this fails, what should be used
