L12 - Bone Repair Physiology Flashcards
what is healthy bone physiology a balance between
what controls this and what happens at each end of spectrum
how to classify different bone tructure
– what about:
macroscopic
microscopic
identify in picture
composition of bone
label poc
what are the main cell types
talk about each one
what else is bone
what is bone dominated by
lamellar bone
what is it made of , whats it clled pto fo list
labelllll
where do osteocytes come from
pto
osteoblasts – what becomes of them?
osteoclasts
function?
what are they like
what is their precurser what whats that lik
bone constituents
what is it made up of
properties
what are the acellular parts of it
what does the extracellular matrix contain (pto)– properties of that
what else
glycoasaminoglycans
what does it do and where is it abundant
also growth factors
—what do they do
how is bone remoddelled and where
what does bone form as and via what (name of processes)
what factors govern remodelling (2)
mechanical stress
what does this do
what detects it and what causes tis to happen
bisphosphonates
whats it for
give eg
what does it do
what is it like
alendronate
what drugs are ther for osteoporosis and what do they do (work)
pto
teriparatide
denosumab
what is osteopetrosis
genetics?
what is the molecular mechanism (why)
what happens and where
what are the symptoms
what are the phases of fracture healing – list
names
reactive phase
soft callus formation
hard callus formation
remodelling
explain phases of fracture healing –
reactive phase
soft callus formation
hard callus formation
remodelling
what hormones regulate calcium and
HOWWW
PTH
Vit D
Calcitonin
