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Neuroscience > Stuff I REALLY need To Know > Flashcards

Stuff I REALLY need To Know Flashcards

1
Q

What kind of drugs should be taken without food

A

Covalent bonded drugs (lipids)

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2
Q

What kinds of drugs should be taken with food?

A

Polar bonded drugs (acids)

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3
Q

Polar bonded drugs are..

A

Acids

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4
Q

Covalent bonded drugs are

A

Lipids

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5
Q

Why should you take polar bonded foods with food

A

Acids are readily absorbed across stomach lining (alcohol)

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6
Q

Why should weak bases be taken without food?

A

It can’t be absorbed till it passes through stomach and into intestine

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7
Q

What are capillaries made of

A

Endothelial cells

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8
Q

What do endothelial cells do to promote BBB

A

Form a tight junction

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9
Q

How are certain molecules like amino acids, glucose and fats carried across endothelial membrane

A

Through active transport

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10
Q

What regions lack a BBB

A

Pituitary
Postrema
Pineal gland

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11
Q

What are glial cells purpose in the BBB

A

Provide route for exchange of food and waste between capillaries and brains extracellular fluid

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12
Q

Active transport systems

A

Pumps that are specialized for particular substance

In BBB

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13
Q

Why is it important for tight BBB

A

Electrical activity of neurons depend on certain extracellular fluid concentration of ions

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14
Q

Seven major processes a drug can modify to influence synaptic transmission

A 
Synthesis 
Storage 
Release
Receptor interaction 
Inactivationreuptake 
Degradation
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15
Q

Examples of agonist function of drugs

A 
Serves as NT precursor 
Stimulates release of NT 
Stimulates postsnyptic receptors 
Blocks auto receptors to increase release 
Inhibits NT degradation 
Blocks reuptake
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16
Q

A drug is an antagonist if it does these things

A 
Inhibits synthesis of NT 
prevents storage of NT in vesicle 
Inhibits release of NT 
blocks postsnyptic receptors 
Stimulates autoreceptors
17
Q

Why can lithium cross BBB and displace K+ and Na +

A

It’s smaller than K+ and Na+

It’s close to them on periodic table

18
Q

What brain part is in mesolimbic pathway

A

Caudate nucleus

19
Q

What parts of brain are in nigrostriatial

A

Cerebellum
Central tegmentum
Nucleus accumbens in basil ganglia

Neuroscience (20 decks)

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