Stuff I REALLY need To Know Flashcards
What kind of drugs should be taken without food
Covalent bonded drugs (lipids)
What kinds of drugs should be taken with food?
Polar bonded drugs (acids)
Polar bonded drugs are..
Acids
Covalent bonded drugs are
Lipids
Why should you take polar bonded foods with food
Acids are readily absorbed across stomach lining (alcohol)
Why should weak bases be taken without food?
It can’t be absorbed till it passes through stomach and into intestine
What are capillaries made of
Endothelial cells
What do endothelial cells do to promote BBB
Form a tight junction
How are certain molecules like amino acids, glucose and fats carried across endothelial membrane
Through active transport
What regions lack a BBB
Pituitary
Postrema
Pineal gland
What are glial cells purpose in the BBB
Provide route for exchange of food and waste between capillaries and brains extracellular fluid
Active transport systems
Pumps that are specialized for particular substance
In BBB
Why is it important for tight BBB
Electrical activity of neurons depend on certain extracellular fluid concentration of ions
Seven major processes a drug can modify to influence synaptic transmission
Synthesis Storage Release Receptor interaction Inactivationreuptake Degradation
Examples of agonist function of drugs
Serves as NT precursor Stimulates release of NT Stimulates postsnyptic receptors Blocks auto receptors to increase release Inhibits NT degradation Blocks reuptake
A drug is an antagonist if it does these things
Inhibits synthesis of NT prevents storage of NT in vesicle Inhibits release of NT blocks postsnyptic receptors Stimulates autoreceptors
Why can lithium cross BBB and displace K+ and Na +
It’s smaller than K+ and Na+
It’s close to them on periodic table
What brain part is in mesolimbic pathway
Caudate nucleus
What parts of brain are in nigrostriatial
Cerebellum
Central tegmentum
Nucleus accumbens in basil ganglia
