Stroke Flashcards
Definition - Sudden/Gradual disturbance of cerebral function of vascular origin that either causes ____ or symptoms last over ___ hours
Sudden
Death
Over 24 hours
What 4 things do you need to find out about the stroke
Type of stroke
Size of stroke
Laterality of stroke
Cause of stroke
Driving rules following stroke
Advise patient not to drive for a month after the stroke but no need to tell the DVLA
What are the 2 types of stroke
Haemorrhage
Ischaemia/infarct
Haemorrhagic stroke - definition
Bleeding from an artery due to a rupture/leak
Haemorrhagic stroke - causes
Structural abnormality - tumour
Hypertensive
Amyloid angiopathy
Subarachnoid haemorrhage
Whats the most common cause of a non-traumatic subarachnoid haemorrhage
PKD (berry aneurysm)
Infarct/ischaemia - more/less common than haemorrhage?
More common
Infarct/ischaemia - definition
Interruption of cerebral blood flow due to a thrombus or embolus
Infaract/ischaemia is more common in males/females?
Males
Infarct/ischaemia - thrombotic stroke - most commonly affects which artery?
Middle cerebral artery
Infarct/ischaemia - embolic stroke - most occlusions occur in the branches of which artery?
Middle cerebral artery
Red thrombus
Cardioembolic clot
White thrombus
Atheroembolic clot
What is the most severe type of stroke?
Total Anterior Circulation Syndrome (TACS)
A large/small area of brain is affected with a Total Anterior Circulation Syndrome (TACS)
Large area of brain affected
Total Anterior Circulation Syndrome (TACS) - clinical features
Ipsilateral motor (hemiplegia) and/or sensory deficit involving at least 2 of: Face Arm Leg \+ Visual field defect: Homonymous hemianopia \+ Cortical dysfunction - dysphasia - neglect
Partial Anterior Circulation Syndrome (PACS) - definition
Less severe than TACS as there is a smaller area of brain affected and therefore there are slightly less severe symptoms and signs
Partial Anterior Circulation Syndrome (PACS) - clinical features
2 or 3 features present in TACS - hemiplegia - visual field defect - cortical dysfunction: dysphasia, dysphagia OR Isolated cortical dysfunction - dysphasia - weakness - pure motor/sensory signs less severe than in lacunar syndromes
Lacunar Syndrome (LACS) - definition
Small infarcts in the deeper parts of the brain (basal ganglia, thalamus, white matter) and in the brainstem
Which type of stroke has the best prognosis?
Lacunar syndrome
Lacunar syndrome (LACS) - causes
Hypertension
Occlusion of a single deep penetrating artery
Blockage in the small branch of the arteries
Lacunar syndrome (LACS) - clinical features
Pure motor hemiparesis OR pure sensory deficit of one side of the body OR an ataxic hemiparesis Affects any 2 of the following - face - arm - leg
NO visual field defect
It is either PURE motor or PURE sensory
Posterior circulation syndrome (POCS) affects which 2 arteries
Vertebral arteries
Basilar arteries
Posterior circulation syndrome (POCS) - clinical features
Ipsilateral CN palsies with contralateral motor and/or sensory deficit
isolated homonymous hemianopia
cortical blindness
Cerebellar deficits without ipsilateral motor/sensory signs
Unilateral/bilateral motor and/or sensory deficits
Carotid artery disease - clinical features
Contralateral weakness or sensory loss
If dominant hemisphere is affected then there may be aphasia or apraxia
Middle cerebral artery occlusion - clinical features
Weakness predominantly in contralateral face and arm
Anterior cerebral artery occlusion - clinical features
Weakness and sensory loss in contralateral leg
In most people, the RIGHT side of the brain is the dominant hemisphere. True or false?
False
- Left side is most dominant in 95% of people
Functions of the dominant hemisphere
Speech and language
Reasoning
Written language
Numeracy skills
Functions of the non-dominant hemisphere
Creativity
Music
Artistic awareness
Spacial orientation
If someone has a stroke affecting the RIGHT/LEFT side of the brain, they tend to have more disability from it
Left side = more disability
If someone has a stroke affecting the left side of the brain, it will affect the left side of the body. True or false?
False
- affects right side of the body
Name 3 possible causes of stroke
Arteriosclerotic
Hypertension
Atrial fibrillation
What is the most common cause of stroke
AF
TIA - definition
Transient obstruction of blood flow causing a sudden onset of symptoms that typically last for an hour but not more than 24 hours
TIA - there is evidence of an acute infarction. True or false?
False
Stroke like features but episode lasts less than 24 hours. What is the likely diagnosis?
TIA
TIA is treated the same as a stroke. True or false?
True
TIA - clinical features
Lasts less than 24 hours
Cortical symptoms: facial or limb weakness, sensory disturbance
Speech abnormalities: dysphasia, dysarthria
Visual disturbance
CN involvement
Memory disturbance
What are the benefits of the rapid access neurovascular clinic (TIA) ?
Drastically reduces the incidence of a subsequent TIA or stroke
TIA - medical interventions
Statin
Anti platelet drug (aspirin, clopidogrel)
Which scoring system is used to identify whether patients with a TIA are at low or high risk of developing subsequent cerebrovascular injuries?
ABCD2 score
Which scoring system weighs up how likely it is to have a stroke?
Rosier score
Stroke - clinical features vary between patients. Why is this?
Clinical features depend on the area of brain affected
Stroke - clinical features develop rapidly/slowly?
Rapidly
Stroke - clinical features
Speech disturbance Vision disturbance Facial weakness Contralateral limb weakness or sensory loss Cerebellar signs
Stroke - clinical features - speech disturbance
Dysarthria
- unclear articulation of speech that is otherwise linguistically normal
Dysphasia
- receptive (wernickes)
- expressive (brocas)
Stroke - clinical features - vision disturbance
Visual field defect
Visual inattention
What is the most common visual field defect in a patient with a stroke?
Contralateral homonymous hemianopia
Stroke - clinical features - facial weakness - a stroke can affect the UMN/LMN of which CN ?
UMN of CN VII
Since a stroke affects the UMN of CNVII, on the affected side the patient will be unable to smile and raise eyebrows. True or false?
False
- will be unable to smile
- ability to raise eyebrows are preserved
what are these features suggestive of:
- sudden onset thunderclap headache
- N+V
- photophobia
- neck stiffness
Subarachnoid haemorrhage
Stroke - what differentiates between haemorrhage vs infarct type of stroke?
Imaging
- Brain CT
Stroke - investigations - urgent imaging - what is the first line imaging investigation
Brain CT
Stroke - CT scan - haemorrhage
ACUTE blood shows up as white blobs on CT scan
Stroke - CT scan - infarct
darker changes (hypoattenuation) - what you are actually seeing is increased water on the CT scan due to oedema from brain tissue injury
Stroke - CT scan - no bleed detected - what do you treat it as
Infarct
Stroke - if there are no abnormalities seen on CT scan then what investigation do you try?
MRI scan
If a patient presents around 1 week post stroke instead of acutely, it is better to do a CT scan / MRI scan?
MRI scan
What is the first line investigation to determine the aetiology of the stroke?
Carotid US scan
- look for atherosclerosis
If there is an abnormality found on the carotid US scan, which investigation is carried out?
Angiogram
- to identify location of vascular abnormality
A patients swallow may be affected due to their stroke. What is the risk they are at?
Risk of aspiration
If swallow screen results are abnormal, who is the patient referred to?
Speech and language therapist
Acute management of stroke
Thrombolysis
Antiplatelets
Acute management of stroke - thrombolysis - examples
Anteplase
tissue plasminogen activator (IV)
Acute management of stroke - thrombolysis - what is the time limit
Must be given less than 4.5 hours from onset of symptoms
It is safe to thrombolyse someone who has had a bleed.. True or false?
False
Acute management of stroke - anti platelets
300mg aspirin given after stroke (infarct)
Acute management of stroke - anti platelets are given in both infarct and haemorrhages?
False
- just infarcts
Acute management of stroke - anti platelets - CT must be done first to exclude a haemorrhage. True or false?
True
Acute management of stroke - anti platelet - best route of administration?
Orally
Acute management of stroke - thrombolysis - post thromolysis, patients should be given anti platelets immediately. True or false?
False
- given anti platelets after 24 hours
Why is there a risk of getting a DVT and subsequently PE from a stroke ?
Due to immobility
Heparin is useful post stroke for DVT prevention. True or false?
False
- there is a risk of haemorrhage with heparin
Secondary prevention management of stroke - medications
BP management
Cholesterol management
Diabetes control
Anti-thrombotic therapy
Secondary prevention management of stroke - medications - anti-thrombotic therapy
Anti-coagulants
- give if cardioembolic/ if patient has AF
- re-introduced after 2 weeks following a major stroke
Antiplatelets
- if not cardioembolic
- use clopidogrel
Statin cannot be used in cardioembolic / non-cardioembolic disease?
cardioembolic
What is the commonest cause of ischaemic stroke?
AF
Which scoring system is used for patients with AF to determine their risk of having a stroke?
CHADSVASc score
Score of 0 - is any intervention required?
NO
Score above 0 - is any intervention required?
Oral anti-coagulants
A man presents with a weak, numb left arm and leg. It is decided that this is due to an occlusion. Which vessel is likely occluded?
Right anterior cerebral artery
- The anterior cerebral artery supplies the frontal and medial part of the cerebrum. Occlusion causes a weak/numb contralateral left with arm symptoms. The face is spared
A women presents following a stroke with a movement loss on her left side, there is also sensory loss. It affects her left arm and face. On examination she appears to have lost vision in both eyes on the left upper and lower quadrants. What is the likely occluded vessel?
Right middle cerebral artery
- The middle cerebral artery supplies the lateral hemisphere. This causes contralateral hemiparesis, hemisensory loss, contralateral homonymous hemianopia due to the involvement of the optic radiations If the dominant hemisphere is affect it can cause dysphasia If the less domains hemisphere is affect it can cause visuospatial disturbance
Occlusion of which artery would present with contralateral homonymous hemianopia with macula sparing?
Posterior cerebral artery
A women presents with a history of persistent headaches, seizures, weakness of all movements of her left foot. The tone is reduced however has an increase in her reflexes. It is thought this is a lesion, where is the likely lesion?
Right cortex
- The cerebral cortex is the outer layer of neural tissues. Cortical lesions can cause weakness in hands of feet that may present with normal or reduced tone. It however does have increased reflex (upper motor neurone sign).
Cortical lesions affect the contralateral side
Contralateral hemiparesis is caused by a lesion where?
Internal capsule lesions cause contralateral hemiparesis
A man presents with a left hemiplegia with his right eye depressed and pointing outwards. Where is the likely location of this lesion?
Right brainstem lesion.
- CN palsy (III - XII) implies the brain stem is affected on the side of the palsy
Which of the following drugs is given to the majority of patients ASAP after an ishcaemic stroke and continued for 2 weeks? Aspirin Clopidogrel Atorvastatin Warfarin LMWH
Aspirin 300mg
How long (hours) after stroke onset can thrombolysis be administered?
Within 4.5 hours of stroke onset