Motor Neurone Disease Flashcards
Definition
Untreatable and rapidly progressive motor neuron degeneration
Which part of the body does it usually start in?
Extremities
- lower limb or upper limb
There is usually sensory disturbance. true or false?
False
- no sensory disturbance
More common in males/females?
Males
- slightly
What are the different clinical phenotypes on the spectrum?
MND
MND - FTD
FTD - MND
FTD
*FTD = fronto temporal disorder
Classic MND - clinical features
Combination of UMN and LMN signs in bulbar and at least 2 of the following spinal regions:
- lumbosacral
- thoracic
- cervical
Classic MND - most common in men/women of young/old age
Women of old age
Cognitive impairment in FTD
Disinhibition
Socially inadequate
No insight
Clinical features
UMN and/or LMN signs with NO sensory problems
If there are any signs of sensory problems, the diagnosis is NOT MND. True or false?
True
Most common site of onset is the core/extremities?
Extremities
Examples of bulbar symptoms
Dysphasia
Difficulty chewing
Often starts with a unilateral foot drop. True or false?
True
UMN signs
Increased tone (spasticity) Exaggerated reflexes (hyper-reflexia) Extensor plantar responses (+ve babinski sign) Spastic gait Slowed movement
LMN signs
Muscle weakness Muscle wasting Flaccid tone Fassiculations Absent or reduced deep tendon reflexes
