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Classical conditioning
natural response is elicited by a conditioned/learned stimulus that was previously presented with unconditioned stimulus
Operant condition
particular action is elicited because it produces a punishment or reward
Difference between operant condition and classical conditioning
- Operant: voluntary responce
- Classical: Involuntary response
Name 3 types of operant conditioning
Reinforcement
Punishment
Extinction
Reinforcement
target behavior is followed by desired award ( positive reinforcement) or removal of aversive stimulus ( negative reinforcement)
Punishment
repeated application of averse stimulus (positive) or removal of desired reward (negative) to extinguish unwanted behavior
Extinction
discontinuation of reinforcement eventually eliminates behavior
Transference
patient projects feelings about formative or other important persons into physician
Countertransference
doctor projects feelings about formative or other important persons into patient
psychiatrist is seen as parent
transference
patient reminds physician of younger sibling
countertransference
Tantrum
- acting out
- expressing unacceptable feelings and thoughts through actions
A common reaction in a newly diagnosed AIDS cancer patients
- Denial
- Avoiding the awareness of some painful reality
Mother yells at her child, because her husband yelled at her
- Displacement
- Transferring avoided ideas and feelings to a neutral person or object
Extreme forms can result in dissociative identity disorder (multiple personality disorder)
- Dissociation
- temporary, drastic change in personality, memory, consciousness, or motor behavior to avoid emotional stress
Adults fixating on video games
- Fixation
- Partially remaining at a more childish level of development
A patient boasts about his physician and his accomplishments while ignoring any flaws
- Idealization
- Expressing extremely positive thoughts of self and others while ignoring negative thoughts
Abused child later becomes child abuser
- identification
- modeling behavior after another person who is more powerful (though not necessarily admired)
In a therapy session, patient diagnosed with cancer focuses only on rates of survival
- Intellectualization
- Using facts and logic to emotionally distance oneself from a stressful situation
Describing murder in graphic detail with no emotional response
- Isolation (of affect)
- Separating feelings from ideas and events
Disgruntled employee is repeatedly late to work
- Passive aggression
- failing to meet the needs/expectations of other as an indirect show of opposition
A man who wants to cheat on his wife accuses his wife of being unfaithful
- Projection
- Attributing an unacceptable internal impulse to an external source
After getting fired, claiming that the job was not important anyway
- Rationalization
- Proclaiming logical reasons for actions actually performed for other reasons, usually to avoid self-blame
A patient with libidinous thoughts enters a monastery
- Reaction formation
- Replacing a warded-off idea or feeling by an (unconsciously derived) emphasis on its opposite
Seen in children under stress such as illness, punishment, or birth of a new sibling ( bedwetting in a previously toilet-trained child when hospitalized)
- Regression
- Involuntary turning back the maturational clock and going back to earlier modes of dealing with the world
A 20-year-old does not remember going to counseling during his parent’s divorce 10 years earlier
- Repression
- Involuntarily withholding an idea or feeling from conscious awareness
A patient says that all the nurses are cold and insensitive but that the doctors are warm and friendly
- Splitting
- Believing that people are either all good of all bad at different times due to intolerance of ambiguity. Commonly seen in borderline personality disorder.
what are the 4 major mature ego defenses
- Sublimation
- Altruism
- Suppression
- Humor
Teenager’s aggression toward his father is redirected to perform well in sports
Sublimation
- replacing an unacceptable wish with a course of action that is similar to the wish but does conflict with one’s value system
Mafia boss makes large donation to charity
Altruism
- alleviating negative feelings via unsolicited generosity
Choosing to not worry about the big game until it is time to play
Suppression
-Intentionally withholding an idea or feeling from conscious awareness; temporary
Nervous medical student jokes about board
Humor
- Appreciating the amusing nature of an anxiety-provoking or adverse situation
Long term deprivation of infant results in
4 W’s
- weak: failure to thrive
- Wordless: poor language
- Wanting: socially
- Wary: lack of basic trust
ADHD is diagnosed before what age
12
How is Rett syndrome inherited? Which gender usually gets it?
X-linked dominant, mostly in girls
Sterotyped hand-wringing and deceleration of head growth should point you towrds
Rett Syndrome
Treatment for conduct disorcer
psychotherapy such as CBT
treatment for oppositional defiant disorder
psychotherapy such as CBT
Conduct disorder patient has a likely hood to have what after 18 years of age
antisocial
Onset age for separation anxiety disorder
7-9
treatment for separation anxiety disorder
CBT, play therapy, family therapy
Coprolalia
involuntary obscene speech
Tourette syndrome is associated with what
OCD and ADHD
treatment for Tourette syndrome
- high-potency antipsychotics
- tetrabenazine
- gaunfacine
- clonidine
neurotransmitter changes in Alzheimer
decrease: ACh
increase: glutamte
neurotransmitter changes in anxiety
decrease: GABA, serotonin
increase: norepinephrine
neurotransmitter change in depression
decrease: norepinephrine, serotonin, dopamine
neurotransmitter changes Huntington disease
decrease: GABA, ACh
increase: dopamine
neurotransmitter changes in Parkinson disease
decrease: dopamine
increase: ACh
neurotransmitter changes in schizophrenia
increase: dopamine
In what order do people loose orientation
time
place
person
Karsakoff syndrome
Amnesia (anterograde more so retrograde) caused by vitamin B1 deficiency
- destruction of mammillary bodies
- confabulations are characteristic
Dissociative amnesia
inability to recall important personal information
Dissociative identity disorder
- formally known as multiple personality disorder
- 2 or more distinct identities
Depersonalization/derealization disorder
Persistent feelings of detachment or estrangement from one’s own body, thoughts, perceptions, and actions or one’s environment
- reality testing intact
define delirium
“waxing and waning” level of consciousness with acute onset
Most common presentation of altered mental status in inpatient setting
delirium
what does EEG show for delirium
diffuse slowing EEG
Delirium reversible or irreversible
reversible
define dementia
decrease intellectual function without affecting level of consciousness
- memory loss
apraxia
inability to perform particular action
aphasia
loss of ability to understand and express speech
agnosia
inability to interpret sensory
Alzheimer patient who develops pneumonia is at increase risk for what
delirium
EEG for dementia
normal
distorted perception of reality characterized by delusions, hallucinations, and/or disorganized thinking
psychosis
Unique, false beliefs that persist despite the facts
delusions
perceptions in the absence of external stimuli
hallucinations
misperceptions of real external stimuli
illusion
when does hypnagogic occur
occurs while going to sleep
when does hypnopompic occur
occurs while waking from sleep
visual hallucinations are commonly seen in who
medical illnes
auditory hallucinations are commonly seen in who
psychiatric features
olfactory hallucinations typically occur when
temporal lobe epilepsy
how is schizophrenia diagnosed
2 of the following and 1 should be from 1-3
- delusions
- hallucinations
- disorganized speech
- disorganized behavior
- negative symptoms
how long does brief psychotic disorder last
less than 1 month
how long does schizophreniform last
1-6 months
frequent use of what drug is associated with psychosis/schizophrenia
cannabis
Schizoaffactive
- Uninterrupted periods of major mood episode ( major depression or manic) concurrent with Schizophrenia criteria A.
- Delusions or hallucinations for 2 or more weeks in the absence of a major mood episode ( manic or depression)
fixed, persistent, false belief system lasting greater than 1 month
delusional disorder
folie a duex
delusional disorder shared by individuals in close relationships
how long must a manic episode last
1 week
how is manic episode diagnosed
causes impairment 3 of DIGFAST -distractibility - insomnia - grandiosity - flight of ideas - agitiation - decrease need for sleep - talkativeness
what is hypomanic episode
same as manic but does not need hospitalization
- 4 days for diagnosis
bipolar I
1 manic episode +/- hypomanic or depressive episode
bipolar II
hypomanic and depressive episode
cyclothymic disorder
2 years
- fluctuating between mild depressive and hypomanic symptoms
diagnose major depressive disorder
5/9 for 2 or more weeks of SIGECAPS
dysthymic ( persistent depressive disorder)
depression lasting 2 years
depressed patients have what changes in their sleep
- decrease slow-wave sleep, REM latency
- increase: REM early in sleep cycle, total REM sleep
postpartum mood distrubances have an onset within
4 weeks
treatment for postpatrum depression
CBT and SSRI
treatment for maternal “blues”
supportive
is ECT safe to use in pregnancy
yes
risk factors for suicide completion
SAD PERSONS
- sex: male
- age: young adult or elderly
- Depression
- Previous attempt
- ethanol
- rational thinking loss
- sickness
- organized plan
- no spouse or support
- stated future intent
What are the symptoms of Panic disorder
PANICS
- Palpitations, paresthesias, depersonlization
- abdominal distress
- nausea
- Intense fear of dying, intense fear of loosing control
- chest pain, chills, choking
- sweating, shaking, shortness of breath
first line treatment for panic atticks
CBT, SSRI, venlafaxine
how do you diagnose panic attacks
attack followed by 1 month of 1 of:
- persistent concern of additional attacks
- worrying about consequences of attack
- behavioral change related to attacks
Does the person recognize fear is excessive in specific phobia
yes
what is social anxiety disorder
exaggerated fear of embarrassment in social situations
treatment for social anxiety disorder
CBT, SSRI, Venlafaxine
- for occasional anxiety-inducing situations: benzodiazepine or beta-blocker
Agroaphobia
exaggerated fear of open or enclosed places
what is agoraphobia associated with
panic disorder
treatment for agoraphobia
CBT, SSRI and MAO inhibitors
How long must generalized anxiety disorder last
greater than 6 months
first line treatment for generalized anxiety disorder
CBT, SSRI, SNRI
second line treatment for generalized anxiety disorder
Buspirone, TCA, Benzodiazepines
adjustment disorder
emotional symptoms (anxiety, depression) causing impairment following an identifiable psychosocial stressor (divorce, illness) - lasting less than 6 months
treatment for adjustment disorder
CBT, SSRI
difference between obsessive-compulsive disorder and obsessive-complusive personality disorder
compulsive disorder: ego-dystonic
personality: ego- sync
treatment for obsessive-compulsive disorder
CBT, SSRI, clomipramine
body dysmorphic disorder
preoccupation with minor or imagined defect in appearance
- impaired functioning
treatment for body dysmorphic disorder
CBT
treatment for post-traumatic stress disorder
CBT, SSRI, venlafaxine
how long must post-traumatic stress disorder last
greater than 1 month
How long does acute distress disorder last
between 3 days and 1 month
Malingering
patient consciously fakes, profoundly exaggerates, or claims to have a disorder in order to attain a specific secondary external gain
factitous disorder
patient consciously creates physical and/or psychological symptoms to order assume sick role, primary gain
Munchausen sydnrome
factitious disorder imposed on self
Manchausen syndrome by proxy
factitious disorder imposed on another
Somatic symptoms disorder
variety of bodily complaints (pain, fatigue) lasting for months to years ( unconscious)
Conversion disorder
loss of sensory or motor function (paralysis, blindness, mutism) following an acute stressor
la belle indifference
loss of sensory or motor function, often following an acute stressor, patient is aware of but sometimes indifferent toward symptoms, in conversion disorder
illness anxiety disorder
excessive preoccupation with acquiring or having a serious illness, minimal somatic symptoms
pseudocyesis
false, nondelusional belief of being pregnant
one word to describe cluster A, B, C personality disorders
Weird, wild, worried
personality A
Paranoid
Schizoid
Shizotypal
personality B
Antisocial
Boderline
Histrionic
Narcissistic
Personality C
Avoidant
Obsessive-compulsive
dependent
refeeding syndrome
- increase insulin
- hypophosphotemia
- cardiac complications
what is the BMI in anorexia
less than 18.5
binge eating disorder
regular episodes of excessive, uncontrollable eating without inappropriate compensatory behavior
binge eating disorder increases the risk for what
diabetes
transsexualism
desire to live as the opposite sex
transvestism
paraphilia, wearing clothes of the opposite sex
sleep terror disorder occurs when at night?
during non-REM sleep
when do nightmares occur at night
REM
what causes narcolepsy
decrease hypocretin production in lateral hypothalamus
cataplexy
loss of all muscle tone following strong emotional stimulus, such as laughter in some patients
treatment of narcolepsy
daytime stimulants: amphetamines, modafinil
night time: sodium oxybate
6 stages of overcoming substance addiction
- precontemplation
- contemplation
- preparation/determination
- action/willpower
- maintenance
- relapse
what is a sensitive indicator of alcohol use
gamma- glutamyltransferase
how do you treat opioid intoxication
naloxone
how do you treat opioid withdrawel
methadone or buprenorphine
treatment for cocaine overdose
alpha blockers
benzodiazepines
ataxia, nystagmus, violence and memory loss is what overdose
phencyclidine
difference between phencyclidine and lysergic acid diethylamide
nystagmus is phencyclidine
MOA of naloxone and buprenorphine
antagonist and partial agonist
MOA of naltrexone
long-acting opioid antagonist
treatment for alcoholism
disulfiram
when do delirium tremens peak from alcohol withdrawal
2-4 days after last drink
when do alcoholic hallucinosis peak from alcohol withdrawal
12-48 hours
MOA of methylphenidate
increase catecholamines ( norepinephrine and dopamine) in synaptic cleft
“-azines”
antipyschotics
high potency antipyschotics
Try to Fly High
Trifluoperazine
Fluphenazine
Haloperidol
Low potency antipsychotics
Cheating Thieves are Low
Chlorpromazine
Thioridazine
side effects of high potency antipsychotics
extrapyramidal symptoms
side effects of low potency antipyschotics
anticholinergic
antihistamine
alpha1 blockade effect
side effect of chlorpromazine
corneal deposits
side effect of thioridazine
retinal deposits
treatment for extrapyramidal side effects from antipsychotics
Benztropine
Diphenhydramine
Benzodiazepine
side effect from blocking muscarinic receptors
dry mouth
constipation
side effects from blocking alpha1
orthostatic hypotension
side effects from blocking histamine
sedation
what is tardive dyskinesia
orofacial chorea
what is neuroleptic malignant syndrome
FEVER
fever encephalopathy vitals unstable enzymes increase, creatine kinase Rigidity of muslces
what is the onset of NMS symptoms for antipsychotics
ADAPT
days: acute dystonia
months: akathisia
years: tardive dyskinesia
what is a common side effect for both atypical and typical antipsychotics
prolonged QT interval
MOA for atypical antipsychotics
D2 antagonist
Serotonin, alpha 1 and histamine 1 blocker antagonist
Lithium side effects
LMNOP
Lithium Movement ( tremor) Nephrogenic diabetes insipidus hypOthyroidism pregnancy ebstein anomaly
drug contraindications for lithium
Thiazide
Ace inhibitor
NSAIDS
(any drug that decreases GFR)
MOA for buspirone
stimulates serotonin receptors
what is Buspirone used to treat
generalized anxiety disorder
compare buspirone with benzos
buspirone: does not cause sedation, addiction, or tolerance
- does not interact with alcohol
Buspirone how long does it take to start working
1-2 weeks
Name the SSRI
Fluoxetine
Paroxetine
Sertaline
Citalopram
MOA for SSRI
Serotonin reptake inhibitors
how long does it take for SSRI to take affect
4-8 weeks
clinical use for SNRI
Depression
Generalized anxiety disorder
Diabetic neuropathy
Adverse effects of SNRI
Increase Blood Pressure
sedation
nausea
What is Venlafaxine specifically indicated for
social anxiety disorder
panic disorder
PTSD
OCD
Characterize serotonin syndrome
- neuromuscular Activity (clonus, hyperflexia)
- Autonomic stimulation (hyperthermia)
- Agitation
what is used to treat serotonin syndrome
cyproheptadine
MOA for tricyclic antidepressants
block repute of norepinephrine and serotonin
Side effects of tricyclic antidepressants
sedation
alpha 1 blockade (postural hypotension)
anticholinergic (dry mouth, urinary retention, tachycardia)
prolong QT interval
treatment for tricyclic antidepressents and why
NaHCO3- arrhythmias are due to Na channel inhibition
Name the Monoamine Oxidase inhibitors
MAO Takes Pride In Shanghai Tranylcypromine Phenelzine Isocarboxazid Selegiline
MOA of MAOI
increases levels of amine neurotransmitters ( norepinephrine, serotonin, and dopamine)
Clinical use for MAOI
atypical depression
anxiety
adverse effects of MAOI
Hypertensive crisis ( with tyramine) CNS stimulation
what is MAOI contraindicated with
SSRI TCA St. John's wort mepredine dextromethorphan
Can a patient take another serotonergic drug with MAOI?
wait 2 weeks after stopping MAOI before starting
What are the atypical antidepressants
Bupropion
Mirtazapine
Trazodone
Vernicline
MOA for Bupropion
Increase norepinephrine and dopamine
Bupropion toxicity
seizures in anorexic or bulimic
headache
MOA for Mirtazapine
- alpha2-antagonist (increase release of NE and 5-HT)
- Potent 5-HT2 and 5-HT3 antagonist
- H1 antagonist
Toxicity for Mirtazapine
- sedation
- weight gain, increase appetite
- dry mouth
MOA for Trazadone
blocks 5-HT2, Alpha1-adrenergic and H1 receptors
toxicity for Trazadone
sedation, priapism
MOA of Varenicline
Nicotonic ACh receptor partial agonist
what drugs are used for smoking cessation
Bupropion
Varenicline
Which atypical antidepressant does not cause sedation
Bupropion