Stem Cell Origins (19)

Question 1

What is a feature of the distal tip found in C. elegans?

a. It keeps germ cells in a meiosis stem cell like state
b. It down-regulates delta-notch signalling
c. It up-regulates mitosis specific genes
d. It is present in the intestine

Answer 1

c. It up-regulates mitosis specific genes

Question 2

What is not a feature of differentiation of GSCs in the drosophila ovary?

a. The terminal filament secretes the UPD cytokine
b. BMP repressed BAM in GSCs
c. UPD activates BMP in cap cells
d. As GSCs move away from the niche, BMP signalling is up-regulated

Answer 2

d. As GSCs move away from the niche, BMP signalling is up-regulated

Question 3

What is not a feature of differentiation of GSCs in the drosophila testis?

a. Once far enough away from BMP signalling, differentiation occurs immediately
b. Hub cells secrete UPD which activates BMP in cyst stem cells
c. BAM is repressed in GSCs due to BMP signalling
d. Differentiation leads to the formation of spermatogonia

Answer 3

a. Once far enough away from BMP signalling, differentiation occurs immediately

Question 4

What is true about BAM mutants?

a. Loss of bam in the ovary represses proliferation of GSCs
b. Loss of bam in the testis leads to proliferation of spermatogonia
c. Loss of bam in the ovary down-regulates BMP signalling
d. Loss of bam in the testis leads to proliferation of GSCs

Answer 4

b. Loss of bam in the testis leads to proliferation of spermatogonia

Question 5

What is involved in the division of drosophila intestinal stem cells?

a. They only give rise to more intestinal stem cells
b. They directly divide into enterocytes and enteroendocrine cells
c. They can produce enteroblasts which give rise to specific intestinal cell types
d. The process depends on UPD and BAM signalling

Answer 5

c. They can produce enteroblasts which give rise to specific intestinal cell types

Question 6

What is a feature of sponges?

a. Cells form tissues and organs
b. Layers contain the same cell types
c. There is extensive neuronal networks and epithelial tissues
d. The cells are arranged loosely and mesenchyme like

Answer 6

d. The cells are arranged loosely and mesenchyme like

Question 7

What is a feature of a Piwi family protein?

a. They are absent in human haematopoietic stem cells
b. Archeocytes and Choanocytes express one and have stem cell properties
c. It is found in stem cell populations of cnidarian
d. It is unique to choanoflagelletes

Answer 7

b. Archeocytes and Choanocytes express one and have stem cell properties

Question 8

What is not a feature of plant meristems?

a. They are stem cell populations
b. They contain zones of cell division, elongation, differentiation
c. The meristem is maintained by Wuschel-expressing cells
d. Meristem secretes Clavata3 which increases the size of the Wuschel domain

Answer 8

d. Meristem secretes Clavata3 which increases the size of the Wuschel domain

Question 9

• C. Elegans can be males or hermaphrodites and the only dividing cells are found in the gonads

Answer 9

. T

Question 10

• Drosophila females have germ line stem cells found in the ovary.

Answer 10

T

Question 11

• The loss of APC has no effect in drosophila.

Answer 11

F