Eye Stem Cells (21)

Question 1

What is not a feature of the retina?

a. It contains glia and 6 types of neurons
b. It has a laminated structure
c. The RPE offers a layer of support
d. It originates from haematopoietic stem cells

Answer 1

d. It originates from haematopoietic stem cells

Question 2

What is true about using iPSC to treat retinal disease?

a. The process has many ethical issues
b. In genetic diseases, the host derived iPSCs have the same mutation that has caused the disease
c. The grafts can be rejected if immunosuppression treatment is not applied
d. The grafts are rarely functional and the use of hESCs is much more efficient

Answer 2

b. In genetic diseases, the host derived iPSCs have the same mutation that has caused the disease

Question 3

What is a beneficial feature of the retina of lower vertebrates?

a. The retina can be used as a xeno-transplant for humans with macular degeneration
b. The retina can grow in the absence of glial cells
c. The retina can regenerate following damage
d. The retina contains rods, but no cones, yet is still functional

Answer 3

c. The retina can regenerate following damage

Question 4

How are glial cells significant?

c. The retina can regenerate following damage
b. They are supported by neurons
c. After light induced retinal damage, they stop proliferating to decrease the risk of mutation from inefficient DNA repair
d. Retinal regeneration can only occur when glial cells are prevented from proliferating

Answer 4

c. The retina can regenerate following damage

Question 5

• RPE keeps photoreceptors alive.

Answer 5

T

Question 6

• When using ESCs to replace lost retinal cells, the age of the donor is not important.

Answer 6

F

Question 7

• Mammalian glia can de-differentiate but only to a small degree.

Answer 7

T

Question 8

• Haematopoietic stem cells cannot prevent degeneration of the retina.

Answer 8

F