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Pharmacology 2 > SSRIs > Flashcards

SSRIs Flashcards

1
Q

“pram”, “ine” suffix

A

SSRIs
Selective serotonin reuptake inhibitors

Antidepressants

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2
Q

Suffix
SSRIs / Selective serotonin reuptake inhibitors

A

“pram”, “ine”

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3
Q

Drug class
SSRI

A

Antidepressants

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4
Q

SSRI a.k.a.

A

Selective serotonin reuptake inhibitors

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5
Q

Generic drug names
SSRIs

A

Citalopram
Dapoxetine
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

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6
Q

Indication
SSRIs

A

Major depression

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7
Q

MOA
SSRIs

A

SSRIs selectively inhibit the presynaptic reuptake of serotonin

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8
Q

Precautions
SSRIs

A

Bipolar disorder—all antidepressants may provoke a manic episode when used in people with bipolar disorder
Risk of bleeding

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9
Q

Adverse effects
SSRIs

A

nausea, diarrhoea, agitation, insomnia, drowsiness, tremor

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10
Q

Counselling
SSRIs

A

SSRIs are usually taken in the morning to minimise insomnia, but if somnolence occurs, they can be given in the evening.
Do not drive or operate machinery until you know how this medicine affects you.
Do not stop taking this medicine suddenly

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11
Q

Practice points
SSRIs

A
  • SSRIs are less likely to alter ability to drive or operate machinery than TCAs
    in depression,
  • increasing the SSRI dose may not provide further improvement
  • increased suicidal thoughts and behaviour can occur soon after starting antidepressants, particularly with some SSRIs in young people; monitor patients frequently and carefully early in treatment
  • sexual dysfunction is an adverse effect that may affect compliance
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12
Q

Drug class and indication

Citalopram

A

SSRI
Major depression

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13
Q

Drug class and indication

Escitalopram

A

SSRI
Major depression
GAD
Social phobia
OCD

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14
Q

Drug class and indication

Fluoxetine

A

SSRI
Major depression
OCD
Premenstrual dysphoric disorder

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15
Q

Drug class and indication

Fluvoxamine

A

SSRI
Major depression
OCD

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16
Q

Drug class and indication

Paroxetine

A

SSRI
Major depression
OCD
Panic disorder
GAD
PTSD
Social phobia

GAD = generalised anxiety disorder

17
Q

Drug class and indication

Sertraline

A

SSRI
Major depression
OCD
Panic disorder
Social phobia
Premenstrual dysphoric disorder

18
Q

Drug interactions
SSRIs

A
  • SSRIs can cause serotonin toxicity; administration with other drugs that may contribute to serotonin toxicity
  • SSRIs can affect platelet aggregation so that combinations with other drugs* that affect the clotting process may increase the risk of bleeding
  • MAOIs + SSRIs = Serotonin toxicity
  • SNRIs + SSRIs = Serotonin toxicity
  • tricyclic antidepressants + SSRIs = Serotonin toxicity
  • triptans + SSRIs = Serotonin toxicity
  • warfarin + SSRIs = risk of bleeding

Pharmacology 2 (41 decks)

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