Factor Xa inhibitors a.k.a. novel oral anticoagulants (NOAC) Flashcards
Generic drug names
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
Apixaban
Fondaparinux
Rivaroxaban
“aban” Suffix
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
Suffix
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
“aban”
MOA
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
Selectively inhibit factor Xa, blocking thrombin production, conversion of fibrinogen to fibrin, and thrombus development.
What does thrombin do?
thrombin is in blood and lumps together to form clumps
Precautions
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
Risk of bleeding
Precautions and adverse effect
Anticoagulants
Risk of bleeding
Adverse effects
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
bleeding, signs of bleeding (eg anaemia)
Counselling
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
Take oral meds at the same time everyday
Practice points
Factor Xa inhibitors / NOAC
NOAC = Novel oral anticoagulants
regular renal function monitoring
notify dr if bleeding
Drug class and indications
Apixaban
NOAC - Factor Xa inhibitor
* Non-valvular AF and a high risk of stroke or systemic embolism
* Prevention of VTE
* Treatment of acute VTE
NOAC = Novel oral anticoagulants
Drug class and indication
Fondaparinux
NOAC - Factor Xa inhibitor
* Prevention of VTE
* Treatment of VTE
* Treatment of unstable angina or non-STEMI
* Treatment of STEMI
NOAC = Novel oral anticoagulants
Drug class and indication
Rivaroxaban
NOAC - Factor Xa inhibitor
* Prevention of VTE
* Treatment of acute VTE
* Non-valvular AF and a high risk of stroke or systemic embolism
* Stable coronary artery disease (CAD) or peripheral artery disease (PAD); use with aspirin
NOAC = Novel oral anticoagulants
Drug interactions
Anticoagulants
Avoid drugs that increase risk of bleeding
