Calcium channel blockers Flashcards

1
Q

Two kinds of Calcium channel blockers

A

Dihydropyridines
Non-dihydropyridines

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2
Q

suffix
Dihydropyridines Calcium channel blocker

A

Pine

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3
Q

Generic names of Dihydropyridines Calcium channel blocker

A

Amlodipine
Amlodipine with atorvastatin
Amlodipine with valsartan
Amlodipine with valsartan and hydrochlorothiazide
Clevidipine
Felodipine
Lercanidipine
Lercanidipine with enalapril
Nifedipine
Nimodipine

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4
Q

Generic names of Non-dihydropyridines Calcium channel blockers

A

Diltiazem
Verapamil
Trandolapril with verapamil

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5
Q

Indication
Calcium channel blockers

A

Hypertension
Angina

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6
Q

MOA
Calcium channel blockers

A

Block inward current of calcium into cells in vascular smooth muscle, myocardium and cardiac conducting system via L‑type calcium channels.

Act on coronary arteriolar smooth muscle to reduce vascular resistance and myocardial oxygen requirements, relieving angina symptoms.

Dihydropyridines act mainly on arteriolar smooth muscle to reduce peripheral vascular resistance and BP. They have minimal effect on myocardial cells.

Non-dihydropyridines: diltiazem and verapamil act on cardiac and arteriolar smooth muscle. They reduce cardiac contractility, heart rate and conduction, with verapamil having the greater effect. Diltiazem has a greater effect on arteriolar smooth muscle than verapamil.

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7
Q

Adverse effects
Calcium channel blockers

A

Most listed adverse effects occur with all calcium channel blockers.

Adverse effects vary between the calcium channel blockers according to their relative effects on vascular, myocardial and conducting tissue.

Dihydropyridines have more pronounced vasodilatory effects than diltiazem and verapamil. Verapamil, and to a lesser extent, diltiazem, reduce cardiac contractility, heart rate and conduction.
Peripheral oedema
Dihydropyridines commonly cause peripheral oedema due to redistribution of extracellular fluid (rather than fluid retention); this does not respond to treatment with diuretics, which may put patient at risk of volume depletion.

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8
Q

Practice points
Calcium channel blockers

A

vasodilatory adverse effects usually subside with continued treatment (may require dose reduction)

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9
Q

Drug class and indication

Amlodipine

A

Dihydropyridine Calcium channel blocker
Hypertension
Angina

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10
Q

Drug class and indication

Amlodipine with atorvastatin

A

Dihydropyridine Calcium channel blocker + statin / HMG-CoA reductase inhibitors
Hypertension or angina, in patients with hypercholesterolaemia or multiple cardiovascular risk factors

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11
Q

Drug class and indication

Amlodipine with valsartan

A

Dihydropyridine Calcium channel blocker + sartan (ARA)
Hypertension

Sartan a.k.a. angiotensin II antagonists and angiotensin receptor antago

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12
Q

Drug class and indication

Amlodipine with valsartan and hydrochlorothiazide

A

Dihydropyridine Calcium channel blocker + Sartan (ARA / ARB/ angiotensin II receptor blocker + Thiazide diuretic
Hypertension

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13
Q

Drug class and Indication

Clevidipine

A

Dihydropyridine calcium channel blocker
Hypertension (short-term use when oral treatment not appropriate)

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14
Q

Drug class and indication

Felodipine

A

Dihydropyridine calcium channel blocker
Hypertension

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15
Q

Drug class and indication

Lercanidipine

A

Dihydropyridine calcium channel blocker
Hypertension

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16
Q

Drug class and Indication

Lercanidipine with enalapril

A

Dihydropyridine calcium channel blocker + ACE inhibitor
Hypertension

17
Q

Drug class and indication

Nifedipine

A

Dihydropyridine calcium channel blocker
Hypertension
Angina

18
Q

Drug class and indication

Nimodipine

A

Dihydropyridine calcium channel blocker
Prevention and treatment of ischaemic neurological deficits following aneurysmal subarachnoid haemorrhage

19
Q

Drug class and indication

Diltiazem

A

Non-Dihydropyridine calcium channel blocker
Angina
Hypertension (controlled release tablet)

20
Q

Drug class and indication

Verapamil

A

Non-dihydropyridine calcium channel blocker
SVT
AF or atrial flutter (ventricular rate control)
Hypertension
Angina

21
Q

Drug class and indication

Trandolapril with verapamil

A

ACE inhibitor + Non-dihydropyridine calcium channel blocker
Hypertension