PCSK9 inhibitors

Question 1

Generic drug names
PCSK9 inhibitors

Answer 1

Alirocumab
Evolocumab

Question 2

Suffix
PCSK9 inhibitors

Answer 2

“cumab”

Question 3

“cumab” Suffix

Answer 3

PCSK9 inhibitors

Question 4

Indication
PCSK9 inhibitors

Answer 4

Dyslipidaemia

Question 5

MOA
PCSK9 inhibitors

Answer 5

Bind to proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibit its activity, increasing LDL clearance from the blood.

Question 6

HDL and LDL

Answer 6

Cholesterol travels through the blood on proteins called “lipoproteins.” Two types of lipoproteins carry cholesterol throughout the body:
LDL = loser = High LDL –> increased risk of heart disease and stroke

HDL = hero = absorbs cholesterol = high HDL –> lowered risk of heart disease and stroke

Question 7

Adverse effects
PCSK9 inhibitors

Answer 7

injection site reactions

Question 8

Drug class and indication

Alirocumab

Answer 8

PCSK9 inhibitor
Hypercholesterolaemia, add-on to optimised lipid-lowering treatment in patients with ischaemic cardiovascular disease

Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins

Question 9

Drug class and indication

Evolocumab

Answer 9

PCSK9 inhibitor
Hypercholesterolaemia, add-on
Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins