PCSK9 inhibitors Flashcards

1
Q

Generic drug names
PCSK9 inhibitors

A

Alirocumab
Evolocumab

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2
Q

Suffix
PCSK9 inhibitors

A

“cumab”

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3
Q

“cumab” Suffix

A

PCSK9 inhibitors

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4
Q

Indication
PCSK9 inhibitors

A

Dyslipidaemia

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5
Q

MOA
PCSK9 inhibitors

A

Bind to proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibit its activity, increasing LDL clearance from the blood.

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6
Q

HDL and LDL

A

Cholesterol travels through the blood on proteins called “lipoproteins.” Two types of lipoproteins carry cholesterol throughout the body:
LDL = loser = High LDL –> increased risk of heart disease and stroke

HDL = hero = absorbs cholesterol = high HDL –> lowered risk of heart disease and stroke

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7
Q

Adverse effects
PCSK9 inhibitors

A

injection site reactions

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8
Q

Drug class and indication

Alirocumab

A

PCSK9 inhibitor
Hypercholesterolaemia, add-on to optimised lipid-lowering treatment in patients with ischaemic cardiovascular disease

Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins

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9
Q

Drug class and indication

Evolocumab

A

PCSK9 inhibitor
Hypercholesterolaemia, add-on
Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins

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