PCSK9 inhibitors Flashcards
Generic drug names
PCSK9 inhibitors
Alirocumab
Evolocumab
Suffix
PCSK9 inhibitors
“cumab”
“cumab” Suffix
PCSK9 inhibitors
Indication
PCSK9 inhibitors
Dyslipidaemia
MOA
PCSK9 inhibitors
Bind to proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibit its activity, increasing LDL clearance from the blood.
HDL and LDL
Cholesterol travels through the blood on proteins called “lipoproteins.” Two types of lipoproteins carry cholesterol throughout the body:
LDL = loser = High LDL –> increased risk of heart disease and stroke
HDL = hero = absorbs cholesterol = high HDL –> lowered risk of heart disease and stroke
Adverse effects
PCSK9 inhibitors
injection site reactions
Drug class and indication
Alirocumab
PCSK9 inhibitor
Hypercholesterolaemia, add-on to optimised lipid-lowering treatment in patients with ischaemic cardiovascular disease
Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins
Drug class and indication
Evolocumab
PCSK9 inhibitor
Hypercholesterolaemia, add-on
Primary hypercholesterolaemia after an inadequate response to, or intolerance of, statins