Beta-blocker Flashcards
Suffix:
Beta-blocker
lol
Drug class
lol
Beta-blockers
Indication
Beta-blocker
Hypertension
Angina
Tachyarrhythmias
MI
Chronic heart failure with reduced ejection fraction as part of standard treatment
Prevention of migraine
MOA
Beta-blocker
Competitively block beta receptors in heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
Beta-blockers reduce heart rate, BP and cardiac contractility; also depress sinus node rate and slow conduction through the atrioventricular (AV) node, and prolong atrial refractory periods.
Adverse effects Beta blockers
bradycardia, hypotension, orthostatic hypotension (especially carvedilol, labetalol), transient worsening of heart failure (when treatment starts), nausea, diarrhoea, bronchospasm
Contraindications
Beta-blockers
CARDIAC Contraindicated in bradycardia (45–50 beats/minute), second‑ or third-degree AV block, sick sinus syndrome (without pacemaker), severe hypotension or uncontrolled heart failure.
Respiratory contraindicated in asthma, alpha 1 selective drugs may be used in controlled asthma and COPD
Myasthenic symptoms (muscle weakness)
Adverse effects
Beta-blockers
- bradycardia,
- hypotension,
- orthostatic hypotension
- bronchospasm,
- dyspnoea,
- fatigue, dizziness
- Mask Hypoglycemia
Can mask signs of hypoglycemia in diabetics
Counselling / practice points
Beta-blockers
Counselling
This medicine may cause dizziness or tiredness
Do not stop taking this medicine suddenly
Practice points
beta-blockers are not usually recommended first line for uncomplicated essential hypertension; they are associated with reduced protection against stroke in the elderly
**when stopping treatment, reduce dosage gradually
Drug class and indication
Atenolol
Beta-blocker
Hypertension
Angina
Tachyarrhythmias
MI
Drug class and indication
Bisoprolol
Beta-blocker
Chronic heart failure with reduced ejection fraction as part of standard treatment
Drug class and Indication
Carvedilol
Beta-blocker
Hypertension
Chronic heart failure with reduced ejection fraction as part of standard treatment
Drug class and indication
Labetalol
Beta-blocker
Hypertension
Hypertensive emergency
Drug class and Indication
Metoprolol
Beta-blocker
Hypertension
Angina
Tachyarrhythmias
MI
Prevention of migraine
Chronic heart failure with reduced ejection fraction as part of standard treatment
Drug class and Indication
Nebivolol
Beta-blocker
Hypertension
Chronic heart failure with reduced ejection fraction as part of standard treatment
Drug class and indication
Propranolol
Beta-blocker
Hypertension
Angina
Tachyarrhythmias
Tetralogy of Fallot, seek specialist advice
MI
Prevention of migraine
Essential tremor
Phaeochromocytoma (with an alpha-blocker)
