Fibrates

Question 1

Generic names of Fibrates contain …

Answer 1

“fib”

Question 2

Drug class containing ‘fib’

Answer 2

Fibrates

Question 3

Generic drug names
Fibrates

Answer 3

Fenofibrate
Gemfibrozil

Question 4

Indication
Fibrates

Answer 4

Dyslipidaemia

Question 5

MOA
Fibrates

Answer 5

Activate peroxisome proliferator-activated nuclear receptors and modulate lipoprotein synthesis and catabolism. They reduce plasma triglyceride, moderately increase HDL and have a variable effect on LDL concentrations.

Question 6

Precautions
Fibrates

Answer 6

Renal
Contraindicated in severe impairment.

Hepatic
Contraindicated when hepatic impairment, primary biliary cirrhosis, gallstones or gall bladder disease are present.

Question 7

Adverse effects
Fibrates

Answer 7

GI disturbances (eg dyspepsia, abdominal pain), increased creatinine concentration (reversible)

Question 8

Practice points
Fibrates

Answer 8

Affects creatine
Therefore … check baseline creatine

Question 9

Drug class and indication

Fenofibrate

Answer 9

Fibrates
Severe hypertriglyceridaemia
Dyslipidaemia associated with type 2 diabetes (second line)

Having a high level of triglycerides in your blood can increase your risk of heart disease.
triglycerides are fat (lipids)
Triglycerides and cholesterol are different types of lipids that circulate in your blood:
* Triglycerides store unused calories and provide your body with energy.
* Cholesterol is used to build cells and certain hormones.

Question 10

What are triglycerides

Answer 10

Having a high level of triglycerides in your blood can increase your risk of heart disease.
triglycerides are fat (lipids)

Question 11

Drug class and indication

Gemfibrozil

Answer 11

Fibrate
Drug for dyslipidaemia
Severe hypertriglyceridaemia with risk of pancreatitis
Mixed hyperlipidaemia and dyslipidaemia associated with diabetes (second line)