SSRI Flashcards

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1
Q

SSRI drugs

A

Flouxetine
Paroxetine
Sertaline
Citalopram

“Flashbacks paralyze senior citizens”

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2
Q

SSRI MOA

A

serotonine reuptake inhibitor

Normally takes 4-8 wks for antidepressant to take effect

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3
Q

Clinical use

A
Depression,
GAD,
Panic disorder,
OCD,
Bulimina,
Social phobias,
PTSD
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4
Q

Toxicity

A

Fewer than TCA:
GI distress
Sexual dysfunction (anorgasmia, low libido)
Serotonin syndrome

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5
Q

Serotonin syndrome

A

Can be caused by anything that increases serotonin
(MAO, SNRI, TCAs)

Hyperthermia, 
Confusion,
Myoclonus,
CV collapse
Flushing,
Diarrhea,
Seizure

Tx: cyproheptadine (5HT2 receptor antagonist)

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