MOA inhibitors

Question 1

MAO drugs

Answer 1

Tranylcypromine,
Phenelzine,
Isocarboxazid
Selegiline (selective MAO-B inhibitor)

“MAO Takes Pride In Shanghai”

Question 2

MOA

Answer 2

Nonselective MAO inhibition increases level of amine NTM (NE, serotonin, dopamine)

Question 3

Clinical use

Answer 3

Atypical depression,
Anxiety
Hypochondriasis

Question 4

Toxicity

Answer 4

1) HTN crises: with tyramine consumption, which is found and wine and cheese.
2) CNS stimulation

Contraindicated with SSRI, TCAs, St. Johns’ Worth, meperidine, dextromethorphan (to prevent serotonin syndrome).