Spondyloarthropathies Flashcards
Name 4 conditions under the umbrella term of spondyloarthropathies
Ankylosing spondylitis
Psoriatic arthritis
Reactive arthritis
IBD associated arthritis
What gene is associated with spondyloarthropathies?
HLA B27
Do spondyloarthropathies generally present symmetrically or asymmetrically?
Asymmetrically
Are spondyloarthropathies typically seropositive or seronegative for RF?
Seronegative (unlike RA)
HLA-B27 is a specific subtype of MHC-I and associated to spondyloarthropathies. What does MHC-I do?
Major Histocompatibility Complex Class I molecules present antigens to cytotoxic T cells
What mnemonic is used for the general features of spondyloarthropathies
SPINEACHE
What does SPINEACHE stand for?
Sausage fingers (dactylitis)
Psoriasis
Inflammatory back pain
NSAIDs good response
Enthesitis (plantar fasciitis, inflamed heel tendon)
Arthritis
Crohn’s disease or Colitis
HLA B27
Eyes (uveitis)