Antiphospholipid syndrome Flashcards
Antiphospholipid syndrome is an a_____ disorder caused by antiphospholipid a_____
autoimmune
antibodies
Antiphospholipid antibodies targets the proteins that bind to phospholipids on the cell surface causing inflammation and increasing the risk of…
thrombosis
Antiphospholipid syndrome can occur in isolation or with another autoimmune conditions, particularly…
SLE
Antiphospholipid antibodies can activate the endothelial cells which line blood vessels and the complement system which both contribute to a p______ state
procoagulant
What are symptoms of antiphospholipid syndrome?
Clots
Livedo reticularis (purple discolouration of skin, lace-like)
Miscarriages
Thrombocytopenia (platelet deficiency)
There is an increased risk of s____, __ and ___
stroke, MI and DVT
Catastrophic antiphospholipid syndrome is a rare complication. What does it involve?
Rapid thrombosis in multiple organs within a few days
What are the 3 specific antiphospholipid antibodies called?
Lupus anticoagulant
Anticardiolipin antibodies
Anti-beta-2 glycoprotein I antibodies
How do you diagnose antiphospholipid syndrome?
Symptoms + presence of the 3 antibodies
(lupus anticoagulant, anticardiolipin antibodies, anti-beta-2 glycoprotein I antibodies
How do you treat antiphospholipid syndrome if a thrombosis has occurred?
Warfarin
How do you treat antiphospholipid syndrome if a thrombosis has not occurred yet?
Prophylactic aspirin
What would you give a pregnant lady instead of wafarin?
Aspirin and heparin (LMWH)