Sjogren's syndrome

Question 1

Sjogren’s syndrome is an a_______ condition affecting the e_____ glands

Answer 1

autoimmune
exocrine

Question 2

What 2 glands are notably affected in Sjogren’s syndrome?

Answer 2

Lacrimal and salivary glands

Question 3

Dry eyes and dry mouth in Sjogren’s syndrome can be called s____ symptoms

Answer 3

sicca symptoms

Question 4

What are symptoms of Sjogren’s syndrome?

Answer 4

Dry eyes
Dry mouth
Dry vagina
Dry skin
Joint pain
Stiffness

Question 5

True or false: Sjogren’s syndrome typically presents in older men

Answer 5

False
Typically middle aged women

Question 6

What is secondary Sjogren’s syndrome?

Answer 6

When Sjogren’s syndrome occurs due to another disease like SLE or RA

Question 7

What antibodies are associated with Sjogren’s syndrome?

Answer 7

Anti-SS-A antibodies (anti-Ro)
Anti-SS-B antibodies (anti-La)

Question 8

What is a term for dry eyes?

Answer 8

Keratoconjunctivitis sicca

Question 9

What is a term for dry mouth?

Answer 9

Xerostomia

Question 10

How do you diagnose Sjogren’s syndrome?

Answer 10

Serology:
Anti-Ro and Anti-la antibodies
ANA is often positive

Schirmer test

Question 11

What is the Schirmer test?

Answer 11

Filter paper under eyes, tears induced. Tears should travel at least 15mm in 5 minutes.
In Sjogren’s, tears travel <10mm

Question 12

How do you treat Sjogren’s syndrome?

Answer 12

Artificial tears, saliva and lubricant
Sometimes hydroxychloroquine is given

Question 13

Sjogren’s syndrome directly increases risk of l______

Answer 13

lymphomas (complicated association)