Paget's disease Flashcards
What is another name for Paget’s disease?
Osteitis Deformans
Paget’s disease is a focal disorder of b___ r______
bone remodelling
In Paget’s disease there is increased o_____ and _____ activity leading to excessive bone turnover
osteoclast and osteoblast
The excessive bone turnover in Paget’s disease is not co-ordinated leading to patchy areas of high density called s____ and low density called l____
sclerosis and lysis
Paget’s disease results in enlarged and misshapen bones, structural problems and increased risk of pathological f_____
fractures
What bones are particularly affected in Paget’s disease?
Axial skeleton
What population does Paget’s disease typically affect?
Older adults
how does Paget’s disease present?
May be asymptomatic
Bone pain
Bone deformity
Bowed tibia
Fractures
Hearing loss
What are neurological symptoms of Paget’s disease?
Nerve compression of CNS leading to deafness
Hydrocephalus due to blockage of an aqueduct
What investigations are taken for Paget’s disease?
X-ray
Blood test
What is urinary hydroxyproline?
Protein constituent of bone collagen which is a good marker of Paget’s disease progression
What would the blood test show in Paget’s disease
Raised ALP (alkaline phosphatase) - increased activity of osteoblasts
What x-ray changes are seen in Paget’s disease?
Bone enlargement
Deformity
Cotton wool appearance in skull
Osteoporosis circumscripta (well-defined osteolytic lesions, less dense)
V-shaped osteolytic defects in long bones
What do blood tests show in Paget’s disease?
Raise alkaline phosphatase
Normal calcium and phosphate
What causes Paget’s disease?
Not fully understood.
Mix of genetic and environmental factors
