Spinal Cord Injury Flashcards
Tetraplegia
Lesions in the cervical (C) region
Paraplegia
Lesions in the thoracic (T), lumbar (L) and sacral (S) regions
Spinal cord injury results in
- tetraplegia
- paraplegia
- complete or incomplete loss of somatic, sensory, and autonomic functions below the lesion level
- spinal bifida
- physiologic impairment
- autonomic troubles
- segmental neuromuscular troubles
SCI C4
artificial support for breathing
SCI C5-C8
Control of shoulder, elbow and wrist, decreased hand function
SCI T1-T6
- Autonomic dysreflexia (an uncoordinated, spinally mediated reflex response called the mass reflex)
- Poor thermoregulation
- Orthostatic hypotension
- Diminished breathing capacity
SCI T6-L2
Respiratory and motor control depends on abdominal muscles
SCI L2-S2
Lack of voluntary control
Normal upper extremities
SCI statistics
50% of those with SCI have tetraplegia
80% are men
SCI’s that are traumatic often occur at an early age
Individuals with SCI have a high risk for the development of secondary complications
Secondary complications of SCI
shoulder pain, urinary tract infection, skin pressure ulcers, osteoporosis, chronic pain, problematic spasticity, depression, CVD, obesity, Type 2 DM
Causes of SCI
Motor vehicle accidents, falls, sports, violence, surgical complications, infection, tumor
Primary Injury
an acute SCI
Secondary Injury
- Systemic injury to neurons and cells nearby
- Cellular Injury 1
- Cellular Injury 2
Cellular Injury 1
Reperfusion of ischemic area leads to free radicals, excitotoxicity, neuronal malfunction, death
Cellular Injury 2
Neutrophils, macrophages, pro-inflammatory cytokines glial scars
(These are barriers to regeneration and recovery)
Systemic injury to neurons and cells nearby
hypotension, hypoxia
Pathophysiology of primary injury
Neuronal damage/disruption -spinal cord, axon, demyelination, cell death Cytokine release -pro-inflammatory -ATP -Potassium Hemorrhage
Primary Injury Processed
Inhibitory Proteolgycan scar
Limited Scwann cell remyelination
Restricted axonal regrowth