Specific Immunity Flashcards
wht area makes blood cells
bone marrow
where do b cells mature
bone marrow
where do t cells mature
thymus
what is the role of non-specific
prevent pathogens from infecting and causing disease
contain infection until specific immunity can clear
present antigens- dendritic cells and macrophages
what are exogenous antigens
outside body
bacteria, protozoa, free viruses, toxins
what are endogenous antigens
produced within cells of body
proteins from replicating viruses
proteins from intracellular bacteria
tumor antigens
what are autoantigens
molecules on normal cells-self-antigens
immune cells normally eliminated
autoimmune disease- not eliminated
what are b cells
reside in spleen and lymph nodes, malt, some circulate
secrete antibdies
what are antibodies
proetins with antigen binding sites
neutralization
opsonization
agglutination
complement
what is igm
first antibody produces
what is igg
most abundant and soluble
can cross placenta
what is iga
mucosal membranes, resists degradation
(neutralization)
what is ige
mast cells
parasites and allergies
what is MHC class 1
found on all nucleated cells
presents endogenous antigens to T cells (cytotoxic)
what is MHC class 2
found on dendritic cells, macrophages, and b cells
presents exogenous antigens to T cells (helper)
what is a t cell receptor
only recognizes antigen attached to MHC
what are helper t cells (MHC 2)
help regulate b cells and cytotoxic t cells
secrete cytokines- direct immune response
activate majority of b cells
direct immune response
activate and recruit innate wbcs
what are cytotoxic t cells (MHC 1)
kill abnormal infected cells
kill cancer cells
apoptosis
recognizes MHC class 1
b and t cells upon recognition of antigen will…
multiply or proliferate
what do memory plasma cells continuously secrete
antibodies
what is the intital response
7-14 days
what is the memory response
2-6 days
what ist type 1 hypersenitivity
ige antibody bound to mast cell
mast cells release many chemicals, histamine being a major player
causes inflammation
smooth muscle constriction
increase in mucus
what is type 4 hypersensitivity
t cell response
antigen is uptaken by APCs
delayed 1-3 days
can cause both cell damage and inflammation
ex. poison ivy
what is acquired immunity
naturall acquired active
naturally acquired passive
artificially acquired active
artificially acquired apssive
who vaccinated in 1796
edward jenner
who vaccinated in 1879
louis pasteur
what is active immunization
attenuated live vaccines (modified live)
not for pregnant or immunosuppresed
what is inactivated
whole agent
sub units
adjuvants
