Infection Flashcards
what is ecology
relationship btwn organisms and their enviornment
what is microbial ecology
microbes interacting with other microbes
microbes interacting with other organisms
what is mutulaism
both benefit
ex. termites and protozoans that digest cellulose
what is commensalism
one benefits the other is not affected
normal flora
what is microbial antagonism
production of bacteriocides or just competition for resources
what is parasitism
disease, one benefits at the others expense
ex. tapeworm
what is an example of mutualism
lichens
what is an example of commensalism
clow fish and anemone
what is an example of parasitism
hookworm
where are the most microorgansims on our body
gut
where is the 2nd most microorganisms on our body
mouth
what sites are without microorganisms
blood
lymph
spinal fluid
internal tissues and organs
when does e coli become dominant
after birt
what is resident flora
adaptive to live inside you
permanent residence
don’t produce disease
microbial antagonism (maintains balance)
what is transient flora
temporary
unable to compete with indigenous microflora
what is destruction of indigenous microflora
microbial antagonism
candida albicans (yeast infections occur when for some reason this species is allowed to grow out of control)
c dif (antibiotic treatment cause) normally kept in check by indigenous microflora
what is contamination
some remain at initial site and become part of normal flora
some transient
infection- become established
what are portals of entry
skin
mucous membranes
whaat is adhesion of microbes
adhesion factors
protozoa and helminths- hooks, suckers, disks
bacteria- adhesins (ligands)
viruses- attachment proteins (ligands)
what is attatchment to host
receptor molecules
prevention of infection
what are symtoms
subjective
what are signs
objective
what is asymptomatic or subclinical
not severe enough to define symptoms
what is eitology
cause
what is LD50
lethal dose that would kill 50% of test population
what is ID50
infectious dose- test popultion infected
what is the pathogenicity of shigella
<10/mL
what is the pathogenicity of vibrio
10^8/mL
what are extracellular enzymes
hyaluronidase and collagenase
coagulase- forms blood clots
kinases- breaks clots
what are toxins
exotoxins- secreted
endotoxins- not really a toxin
what are the exotoxins
cytotoxins- cell
neurotoxins- nerves
enterotoxins- gi tract
what are endotoxins
lipid of LPS
death of bacteria
what are the stages of disease
incubation
prodormal
illness
decline
convalescense
what is the incubation period
no signs or symptoms
what is the prodromal period
vague general symptoms
what is the illness period
most severe s&s
what is the decline period
declining s&s
what is the convalscence period
no s&s
what is the only eradicted disease
small pox
what are the source of infectious diseases in humans
animal reservoirs
human reservoirs
non-living reservoirs (soil, water, food, fomites- hospital bedding)
what is contact transmission
direct
indirect
droplet
what is vehicle transmission
airborne
waterborne
foodborne
what is vector transmission
mechanical
biological
what is direct contact
human to human
what is indirect contact
intermediate
toys, toothebrushes, etc
what is droplet transmission
sneezing
what is waterborne
streams and swimming pools
what is foodborne
poultry, seafood, meat
what is mechanical
on insect bodies
flies and roaches
what is biological
lice, mites, mosquitoes, ticks
got bit