Small group Liver II + cancer

Question 1

SBP can present underwhelmingly (asymptomatic) but can present with hepatorenal syndrome bc they got sicker, what test can you get done?

Answer 1

Diagnostic paracentesis

Question 2

If you have Type 1 Hepatorenal syndrome (HRS) what is the tx?

Answer 2

liver transplant - curative

Question 3

Posthepatic portal HTN can be due to

Answer 3

Hepatic Vein Thrombosis

RHF
Constrictive pericarditis

Question 4

HBV vs HCV, which one has an 85% chance of going on to chronic hepatitis?

Answer 4

HCV

Question 5

The GRADE of chronic liver disease is related to ________.

The STAGE of chronic liver disease is related to _________.

Answer 5

inflammation and necrosis

fibrosis

Question 6

Drug you give to tx hepatic encephalopathy

Answer 6

lactulose
- non-absorbable sugar used as laxative by pulline/retaining water in the colon –> diarrhea to flush NH3 from the colon (less absorbed)

Rifaximin - non absorbable antibiotic - red bacteria that cause NH3

Question 7

Other than HH, what other diseases elevate ferritin?

Answer 7

Infections

INflammatory

• so check CRP and ESR
• if nl then not one of these, prob HH

Question 8

Most commonly affected gene in HH?

Answer 8

HFE
TfR2

HFE
- nothern euro
- Mut C282Y
Homozygosity = disease
Heterozygosity = no diease

Question 9

When would Iron be found in the hepatocyte vs inside macrophages.

Answer 9

Hemochromatosis: inside hepatocytes - storage unit

Hemosiderosis: Inside macrophages (Kupffer) - damage

Question 10

joint symptoms is seen in 44% of ____

Answer 10

hemochromatosis