Review Flashcards
acetaminophen is a hepatotoxin that causes ______ necrosis WITHOUT a significant inflammatory cell infiltrate
centrilobular coagulative necrosis
Acute infxn has Ig_ infxn. Sustained infxn is Ig_
M acute
G for sustained immunity
There is a vaccine for which hepatitis?
A + B
elevated Ig_ is associated with autoimmune hepatitis
IgG
ELEVATED Ig_ IS associated with primary biliary cirrhosis
IgM
PAS-positive, diastase resistant globules in hepatocytes
PASD stain
alpha-1-antitrypsin deficiency
–> emphysema + cirrhosis
PSC dx is ___ in nature
radiologic for strictures
anti smooth muscle antibodies
- IgG
- ana
autoimmune hepatitis
AMA + IgM
Two M’s
PBC
Plasma cell rich interface and centrilobular hepatitis
Autoimmune
plasma cells = autoimmune
PBC population
middle age women
PSC population
Male predominance
Autoimmune hepatitis population
female
Also PBC
Granulomatous lymphocytic cholangitis/florid duct lesion
PBC
Pruritis (itchyness) and jaundice in middle aged women
Primary biliary cirrhosis
misnomer, doesnt have to have cirrhosis