2 Intro to infectious Dis [3]

Question 1

2 leading causes of death from infectious diseases world wide

Answer 1

Pneumonia (8-10%, 10 mil/year)

Diarrhea (2 mil/year)

Question 2

Age group preferentially affected by infectious disease syndromes

Answer 2

diarrheal disease is in the young and old

Question 3

Identify the leading cause of morbidity and death with diarrhea

Answer 3

dehydration

- rehydration is mainstay of therapy

Question 4

Species that cause Noninflammatory diarrhea

Answer 4

Norwalk virus
rotavirus
giardia lamblia
cholera
ETEC

Question 5

Species that cause inflammatory diarrhea

Answer 5

c. jejuni
shigella
salmonella
Ecoli 0157:H7
C. difficile
E. histolytica

Question 6

Inflammatory vs noninflammatory diarrhea

Answer 6

Inflammatory:
- increase temp, WBC, RBC, involves the COLON

NON-inflammatory: (watery)
- involes the SMALL BOWEL

Question 7

Structure of cholera toxin

Answer 7

A:5B

A - active: secretes toxin into epi cells
B - binding: binds to epi cells

Question 8

Signs of dehydration

Answer 8

decrease pulse 
low BP
poor skin turgor
sunken eyes
decreased urine
met acidosis
hypoglycemia
hypokalemia

Question 9

Travelers diarrhea

Answer 9

Enterotoxigenic E. coli (ETEC)

Question 10

Norovirus/Norwalk virus

Answer 10

family/community epidemics (winter) - like rota

transmitted thru: f-o, contamination, shellfish, and water

Older children and adults
(comes fast, goes away fast)