Sleep Drugs - Egleton Flashcards
hypnotics
sleep induced drug
how long can a patient be put on hynotics
should not be sued for more than one month
transient insomnia
few days
short-term insomnia
several weeks
long term insomnia
greater than 3 weeks
name the 5 drugs of BDZ for sleep disorder
Flurazepam Temazepam Triazolam Quazepam Estazolam
what do BDZ do to sleep architecture
alters it
what is the net effect on sleep time for BDZ
increases
what will develop with long term use of BDZ
tolerance
Flurazepam reduces what
sleep induction time
number of awakening
what is the draw back of Flurazepam
long half life, daytime sedation
Temazepam is useful in patients who experience what
frequent wakening
when should Temazepam be given
1-2 hours before desired bedtime
Triazolam is used in what type of patients
recurring insomnia
-patients who have difficulty going to sleep
what is the recommended dosing for Triazolam
intermittently rather then daily b/c tolerance develops over a few days. withdrawal results in rebound insomnia
Zolpidem works on what receptors
BDZ
non-BDZ drug
why is Zolpidem perscribed more
perceives sleep structure
what receptor does Zaleplon attach to
BDZ
non-BDZ drug
what is Zaleplon used for
good for broken sleep
what happens after 1 night of withdrawel of zaleplon
rebound insomnia but soon resolves
compare the half life of Eszopicione and Zolpidem and Zaleplon
longer than Zolpidem and zalelpon
What do Barbiturates do at low concentrations and high concentrations
low: depress CNS activity
high: depress activity of nerve, skeletal muscle, and smooth and cardiac muscle
Mechanism of action of Barbiturates
open channel for longer periods compared to BDZ
Potentiate GABA action
increasing Cl‐ conductance
which Barbiturates induces anesthesia
Thiopental
