SLE, Vasculitis, and Myositis

Question 1

_____ shows endomysial distribution invading non-necrotic fibers, consisting primarily of _____ cell infiltrate

Answer 1

Polymyositis; CTL

Question 2

_____ shows perivascular distribution of inflammatory infiltrate around the periphery of fascicles, consisting of ______ cells.

Answer 2

CD4 T cell, B cells, macrophages, dendritic cells

Question 3

_______ is an antibody against ________ associated with microscopic polyangiitis (MPA).

Answer 3

Perinuclear ANCA; Myeloperoxidase (MPO)

Question 4

_______ is an antibody against proteinase-3 (PR3) in ________.

Answer 4

Cytoplasmic ANCA (c-ANCA); Granulomatosis with Polyangiitis (Wegener’s)

Question 5

________ is an antibody against ________ in Granulomatosis with Polyangiitis (Wegener’s).

Answer 5

Cytoplasmic ANCA (c-ANCA); proteinase-3 (PR3)

Question 6

________ is an antibody against Myeloperoxidase (MPO) associated with _______.

Answer 6

Perinuclear ANCA; microscopic polyangiitis (MPA)

Question 7

Anti-synthetase syndrome most commonly presents with ______.

Answer 7

Interstitial lung disease

Question 8

Antibodies in SLE include _____ (3)

Answer 8

Anti-RBC, Anti-WBC, Anti-Phospholipid (aPL)

Question 9

Antibodies in SLE may be directed against ______ (3)

Answer 9

Anti-dsDNA, Anti-histone, Antibodies to non-DNA non-histone nuclear antigens

Question 10

Cytoplasmic ANCA (c-ANCA) is an antibody against _________ in __________.

Answer 10

proteinase-3 (PR3); Granulomatosis with Polyangiitis (Wegener’s)

Question 11

Evidence suggests that the etiology of dermatomyositis and polymyositis is _____

Answer 11

Viral infection

Question 12

In SLE, >95% of paitents have these antibodies: ____

Answer 12

ANA

Question 13

In SLE, antibody responses to autoantigens require ______ cells.

Answer 13

CD4+ T cells

Question 14

In SLE, immune complex-mediated disease is caused by _______ immune complexes.

Answer 14

Anti-dsDNA-DNA

Question 15

In vasculitis, endothelial cell injury is mediated by ___ cells.

Answer 15

T

Question 16

Large Vessel Arteritis (2)

Answer 16

Giant Cell Arteritis, Takayasu Arteritis

Question 17

Medium Vessel Arteritis (2)

Answer 17

Polyarteritis nodosa, Kawasaki disease

Question 18

Perinuclear ANCA is an antibody against ________ associated with ________.

Answer 18

Myeloperoxidase (MPO); microscopic polyangiitis (MPA)

Question 19

Skin changes in dermatomyositis (5)

Answer 19

Gottron’s Nodules, Heliotrope rash, Shawl sign/V-sign, Mechanic’s hands, Periungal changes/erythema

Question 20

SLE has greatest genetic association with the ______ allele (also some with the ______ allele)

Answer 20

C4A null; HLA-DR3

Question 21

SLE immunofluorescence staining of the glomerulus shows a ______ pattern

Answer 21

Lumpy-bumpy

Question 22

SLE is caused by Type ___ Immunopathology.

Answer 22

II and III

Question 23

SLE is more common in ____ (sex).

Answer 23

Women

Question 24

SLE results from a misdirected recognition of self as foreign, resulting in _____ cell autoimmune processes.

Answer 24

T and B

Question 25

Small Vessel Arteritis - ANCA(-) (3)

Answer 25

Henoch-Schonlein Purpura, Essential Cryoglobulinemic Vasculitis, Cutaneous Leukocytoclastic angiitis

Question 26

Small Vessel Arteritis - ANCA(+) (3)

Answer 26

Wegener’s Granulomatosis/Granulomatosis with Polyangiitis, Eosinophilic Granuloma with Polyangiitis/Churg-Strauss Syndrome, Microscopic Polyangiitis

Question 27

The most common anti-synthetase antibody, _____, targets _______.

Answer 27

Anti-Jo1; histidyl-tRNA synthetase