Hemoglobin, Hemoglobinopathies, and Thalassemia Flashcards
____ has two alpha chains and two delta chains
HbA2
____ has two alpha chains and two epsilon chains
Hb Gower II
____ has two alpha chains and two gamma chains
HbF
____ has two zeta chains and two epsilon chains
Hb Gower
____ has two zeta chains and two gamma chains
Hb Portland
_____ induces production of fetal hemoglobin
hydroxyurea
______ consists of four beta chains
HbH
______ consists of four gamma chains
Hb Barts
______ is an important cause of aplastic crisis in children.
Parvovirus B19
2,3-BPG stabilizes hemoglobin in the ____ conformation
T
As 2,3-BPG increases, oxygen affinity _____ (____ shift)
decreases; right
As carbon dioxide concentration increases, oxygen affinity ____ (___ shift)
decreases; right
As pH increases, oxygen affinity _____ (___ shift)
increases; left
As temperature increases, oxygen affinity _____ (___ shift)
decreases; right
Extramedullary erythropoiesis and frontal bossing are associated with ______.
Thalassemia
Hydrops fetalis is most likely to occur in offspring of ______ descent.
Asian
In sickle cell anemia, bilirubin, LDH, and AST are _____.
increased
In sickle cell anemia, platelet count is _____.
increased
In sickle cell anemia, reticulocytes count is _____.
increased
In sickle celll anemia, RDW is _____.
increased
In thalassemia, bilirubin, LDH, and AST are _____.
increased
In thalassemia, MCV is ______.
decreased
In thalassemia, reticulocyte count is _____.
increased
Methemoglobinemia results in a ____ shift on the hemoglobin binding curve
left
Oxidation of Iron (II) to Iron (III) converts hemoglobin into ______.
methemoglobin
The high affinity conformation is the ___ conformation
R
The low affinity conformation is the ___ conformation
T
What condition is characterized by dark, chocolate covered blood?
Methemoglobinemia
What condition is characterized by headache, malaise, nausea, dizziness; can even have seizures, coma, or myocardial infarction or late neurologic deficits (cognition loss, personality change, movement disorders)?
Carbon Monoxide poisoning
