Hemoglobin, Hemoglobinopathies, and Thalassemia

Question 1

____ has two alpha chains and two delta chains

Answer 1

HbA2

Question 2

____ has two alpha chains and two epsilon chains

Answer 2

Hb Gower II

Question 3

____ has two alpha chains and two gamma chains

Answer 3

HbF

Question 4

____ has two zeta chains and two epsilon chains

Answer 4

Hb Gower

Question 5

____ has two zeta chains and two gamma chains

Answer 5

Hb Portland

Question 6

_____ induces production of fetal hemoglobin

Answer 6

hydroxyurea

Question 7

______ consists of four beta chains

Answer 7

HbH

Question 8

______ consists of four gamma chains

Answer 8

Hb Barts

Question 9

______ is an important cause of aplastic crisis in children.

Answer 9

Parvovirus B19

Question 10

2,3-BPG stabilizes hemoglobin in the ____ conformation

Answer 10

T

Question 11

As 2,3-BPG increases, oxygen affinity _____ (____ shift)

Answer 11

decreases; right

Question 12

As carbon dioxide concentration increases, oxygen affinity ____ (___ shift)

Answer 12

decreases; right

Question 13

As pH increases, oxygen affinity _____ (___ shift)

Answer 13

increases; left

Question 14

As temperature increases, oxygen affinity _____ (___ shift)

Answer 14

decreases; right

Question 15

Extramedullary erythropoiesis and frontal bossing are associated with ______.

Answer 15

Thalassemia

Question 16

Hydrops fetalis is most likely to occur in offspring of ______ descent.

Answer 16

Asian

Question 17

In sickle cell anemia, bilirubin, LDH, and AST are _____.

Answer 17

increased

Question 18

In sickle cell anemia, platelet count is _____.

Answer 18

increased

Question 19

In sickle cell anemia, reticulocytes count is _____.

Answer 19

increased

Question 20

In sickle celll anemia, RDW is _____.

Answer 20

increased

Question 21

In thalassemia, bilirubin, LDH, and AST are _____.

Answer 21

increased

Question 22

In thalassemia, MCV is ______.

Answer 22

decreased

Question 23

In thalassemia, reticulocyte count is _____.

Answer 23

increased

Question 24

Methemoglobinemia results in a ____ shift on the hemoglobin binding curve

Answer 24

left

Question 25

Oxidation of Iron (II) to Iron (III) converts hemoglobin into ______.

Answer 25

methemoglobin

Question 26

The high affinity conformation is the ___ conformation

Answer 26

R

Question 27

The low affinity conformation is the ___ conformation

Answer 27

T

Question 28

What condition is characterized by dark, chocolate covered blood?

Answer 28

Methemoglobinemia

Question 29

What condition is characterized by headache, malaise, nausea, dizziness; can even have seizures, coma, or myocardial infarction or late neurologic deficits (cognition loss, personality change, movement disorders)?

Answer 29

Carbon Monoxide poisoning