Intro to Hematologic Malignancies

Question 1

_______ express TdT

Answer 1

Lymphoblasts

Question 2

A malignancy of hematopoietic cells where the main manifestation is in the blood and marrow

Answer 2

Leukemia

Question 3

A malignancy of hematopoietic cells, derived from lymphocytes or precursors, that presents primarily as a solid mass

Answer 3

Lymphoma

Question 4

A malignancy of hematopoietic cells, derived from myeloid cells or precursor, presenting primarily as a solid mass

Answer 4

Extramedullary Myeloid Tumor

Question 5

ALL is a worse disease in ______ (demographic).

Answer 5

adults

Question 6

ALL is more common in _______ (demographic).

Answer 6

children

Question 7

AML is more common in ______ (demographic).

Answer 7

Older adults (Avg. age: 65)

Question 8

B-lymphoblasts often express ________.

Answer 8

CD19, CD22, and CD79a

Question 9

CD117 is often seen in ______.

Answer 9

Myeloid Cells

Question 10

CD14 is often seen in ______.

Answer 10

Monocytes

Question 11

CD19 is often seen in __-lymphoblasts.

Answer 11

B

Question 12

CD1a is often seen in _______.

Answer 12

T-lymphoblasts

Question 13

CD2 is often seen in __-lymphoblasts.

Answer 13

T

Question 14

CD20 is often seen in _____.

Answer 14

Mature B cells

Question 15

CD22 is often seen in __-lymphoblasts.

Answer 15

B

Question 16

CD3 is often seen in __-lymphblasts.

Answer 16

T

Question 17

CD34 is often seen in ______.

Answer 17

immature cells

Question 18

CD4 and/or CD 8 are often seen in __-lymphoblasts

Answer 18

T

Question 19

CD41 is often seen in _____

Answer 19

Megakaryoblasts

Question 20

CD61 is often seen in _______.

Answer 20

Megakaryoblasts

Question 21

CD64 is often seen in ______.

Answer 21

Monocytes

Question 22

CD7 is often seen in __-lymphoblasts.

Answer 22

T

Question 23

CD79a is often seen in __-lymphoblasts.

Answer 23

B

Question 24

CD99 is often seen in _______.

Answer 24

T-lymphoblasts

Question 25

Chemotherapy treatment that increases risk of acute leukemia

Answer 25

DNA-alkylating agents and Topoisomerase II inhibitors

Question 26

Effects of leukemia that are direct but rare (3)

Answer 26

Thrombotic events (leukostasis), DIC, Infiltration of Tissues (skin, gums, lymph nodes, etc.)

Question 27

Epstein Barr Virus has an oncogenic role in the following lymphomas: ______

Answer 27

Burkitt, Hodgkin, B-Cell Non-Hodgkin

Question 28

Genetic Syndromes associated with increased risk of leukemia

Answer 28

Down Syndrome, Blood Syndrome, Fanconi anemia, ataxia-telangiectasia

Question 29

Group of conditions where a clonal population derived from a neoplastic hematopoietic stem cell takes over the marrow, such that the marrow is not capable of making normal blood cells in one or more lineages

Answer 29

Myelodysplastic Syndrome

Question 30

Immature cells often express ____.

Answer 30

CD34

Question 31

Lymphoblasts specifically express the nuclear enzyme _____.

Answer 31

TdT

Question 32

Mature B cells often express ______, which are not seen in B-lymphoblasts

Answer 32

CD20, sIgG

Question 33

Megakaryblasts often express _____.

Answer 33

CD41, CD61

Question 34

Monocytes often express ____.

Answer 34

CD14, CD64

Question 35

Most common type of childhood cancer

Answer 35

Leukemia

Question 36

Myeloid cells often express _____.

Answer 36

CD117 and myeloperoxidase

Question 37

Myeloperoxidase is often seen in ______.

Answer 37

Myeloid Cells

Question 38

Neoplastic clonal proliferations of the marrow where the clone makes normal functioning blood cells usually in multiple lineages, but makes too many of them in one or more lineages

Answer 38

Myeloproliferative Neoplasm

Question 39

Risk Factors for Acute Leukemia (5)

Answer 39

Previous chemotherapy, tobacco smoke, ionizing radiation, benzene exposure, genetic syndromes

Question 40

sIgG is often seen in _____.

Answer 40

Mature B cells

Question 41

Symptoms/Signs of Neutropenia (2)

Answer 41

Fever, Infections

Question 42

Symptoms/Signs of Thrombocytopenia (3)

Answer 42

Bruising, petechiae, hemorrhage

Question 43

T lineage antigens of immature cells: ____

Answer 43

CD99, CD1a

Question 44

T lymphoblasts often express _____.

Answer 44

CD2, CD3, CD7, CD4 and/or CD8

Question 45

Usually due to rapid accumulation of immature cells in the marrow that replace normal cells, resulting in cytopenias

Answer 45

Acute Leukemias