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Blood and Lymph > CBC, Peripheral Blood and Marrow, and Hematopoiesis > Flashcards

CBC, Peripheral Blood and Marrow, and Hematopoiesis Flashcards

1
Q

____ stimulates basophil production

A

IL-3

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2
Q

____ stimulates eosinophil production

A

IL-5

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3
Q

_______ are anucleate cells in the erythroid lineage

A

reticulocytes and erythrocytes

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4
Q

_______ lineage: _______ -> basophilic normoblast -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> _______

A

Erythroid; Pronormoblast; reticulocyte; erythrocytes

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5
Q

_______ lineage: Myeloblast -> promyelocyte -> myelocyte -> metamyelocyte -> ______ -> ______

A

Granulocyte; band; segmented —–phil

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6
Q

A pale blue inclusion at the periphery of a RBC consisting of condensed RNA is described as _______

A

Dohle Body

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7
Q

Average lifetime of erythrocytes in the peripheral blood

A

120 days

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8
Q

Average lifetime of monocytes in the peripheral blood before becoming macrophages in tissues

A

20 days

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9
Q

Average lifetime of neutrophils in the peripheral blood

A

7-10 hours

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10
Q

Average lifetime of platelets in the peripheral blood

A

8-9 days

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11
Q

Childhood levels of HGB and HCT are _______ than those of adults

A

lower

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12
Q

Denatured/oxidized hemoglobin attached to the inner side of the cell membrane is described as _______.

A

Heinz Bodies

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13
Q

Erythroid lineage: _______ -> basophilic normoblast -> _______ -> orthochromatic normoblast -> reticulocyte -> erythrocytes

A

Pronormoblast; polychromatophilic normoblast

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14
Q

Erythroid lineage: Pronormoblast -> _______ -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> erythrocytes

A

basophilic normoblast; reticulocyte

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15
Q

Erythroid lineage: Pronormoblast -> _______ normoblast -> _______ normoblast -> _______ normoblast -> reticulocyte -> erythrocytes

A

basophilic; polychromatophilic; orthochromatic

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16
Q

Female HCT

A

36-47%

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17
Q

Female normal concentration of RBCs

A

4.2-5.6x10^12/L

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18
Q

Female normal HGB

A

12.1-16.3g/L

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19
Q

Granulocyte lineage: _______ -> promyelocyte -> myelocyte -> metamyelocyte -> _______ -> segmented —–phil

A

Myeloblast; band

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20
Q

Granulocyte lineage: Myeloblast -> _______ -> myelocyte -> _______ -> band -> segmented —–phil

A

promyelocyte; metamyelocyte

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21
Q

IL-3 stimulates ______ production

A

basophil

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22
Q

IL-5 stimulates _______ production

A

eosinophil

23
Q

In bone marrow, the ratio of granulocytic:erythroid precursors should be about ____.

A

3 to 1

24
Q

In the erythroid lineage, the ability to replicate is lost at progession to the _______ stage.

A

Orthochromic normoblasts

25
Q

In the granulcyte lineage, the last cell with replicative ability is the _______

A

myelocyte

26
Q

In the granulocyte lineage, primary granules first appear in the ______ stage.

A

promyelocyte

27
Q

In the granulocyte lineage, the largest cell is the _____

A

promyelocyte

28
Q

In the megakaryocyte lineage, endoreduplication begins in the _____ stage.

A

promegakaryocyte

29
Q

Male HCT

A

39-50%

30
Q

Male Normal concentration of RBCs

A

4.75-6.1x10^12/L

31
Q

Male normal HGB

A

14.3-18.1g/L

32
Q

Megakaryocyte lineage: _______ -> _______ -> megakaryocyte -> platelet

A

megakaryoblast; promegakaryoctye

33
Q

Men have _______ HGB and HCT than women

A

higher

34
Q

Menstruating and pregnant women have _______ HGB and HCT

A

lower

35
Q

Monocyte lineage: _______ -> _______ -> monocyte

A

monoblast; promonocyte

36
Q

Normal Basophil %

A

0-2%

37
Q

Normal Eosinophil %

A

0-6%

38
Q

Normal Lymphocyte %

A

20-50

39
Q

Normal MCH

A

27.5-35pg

40
Q

Normal MCHC

A

32-36g/L

41
Q

Normal MCV

A

80-100fL

42
Q

Normal Monocyte %

A

2-11%

43
Q

Normal Neutrophil %

A

40-72

44
Q

Normal Platelet Count

A

150-400x10^9/L

45
Q

Normal Reticulocyte %

A

0.4-1.7%

46
Q

Normal WBC Count

A

4.0-11.1x10^9/L

47
Q

Nuclear DNA remnants that appear as single, dense, blue dot can be described as_______.

A

Howell-Jolly Bodies

48
Q

RI<1 with anemia indicates _______ production of RBCs

A

decreased

49
Q

RI>2 with anemia indicates ______ production of RBCs

A

increased

50
Q

The largest blood cell is a _______.

A

monocyte

51
Q

This blood cell has a large kidney-shaped nucleus

A

monocyte

52
Q

What is the function of erythropoietin? In what organ is it made?

A

Promote erythropoiesis; kidney

53
Q

What is the function of thrombopoietin?

A

Promote production of megakaryocytes

54
Q

When aggregated ribosomes are present in RBCs, they appear as _____.

A

basophilic stippling

Blood and Lymph (14 decks)

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