CBC, Peripheral Blood and Marrow, and Hematopoiesis Flashcards
____ stimulates basophil production
IL-3
____ stimulates eosinophil production
IL-5
_______ are anucleate cells in the erythroid lineage
reticulocytes and erythrocytes
_______ lineage: _______ -> basophilic normoblast -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> _______
Erythroid; Pronormoblast; reticulocyte; erythrocytes
_______ lineage: Myeloblast -> promyelocyte -> myelocyte -> metamyelocyte -> ______ -> ______
Granulocyte; band; segmented —–phil
A pale blue inclusion at the periphery of a RBC consisting of condensed RNA is described as _______
Dohle Body
Average lifetime of erythrocytes in the peripheral blood
120 days
Average lifetime of monocytes in the peripheral blood before becoming macrophages in tissues
20 days
Average lifetime of neutrophils in the peripheral blood
7-10 hours
Average lifetime of platelets in the peripheral blood
8-9 days
Childhood levels of HGB and HCT are _______ than those of adults
lower
Denatured/oxidized hemoglobin attached to the inner side of the cell membrane is described as _______.
Heinz Bodies
Erythroid lineage: _______ -> basophilic normoblast -> _______ -> orthochromatic normoblast -> reticulocyte -> erythrocytes
Pronormoblast; polychromatophilic normoblast
Erythroid lineage: Pronormoblast -> _______ -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> erythrocytes
basophilic normoblast; reticulocyte
Erythroid lineage: Pronormoblast -> _______ normoblast -> _______ normoblast -> _______ normoblast -> reticulocyte -> erythrocytes
basophilic; polychromatophilic; orthochromatic
Female HCT
36-47%
Female normal concentration of RBCs
4.2-5.6x10^12/L
Female normal HGB
12.1-16.3g/L
Granulocyte lineage: _______ -> promyelocyte -> myelocyte -> metamyelocyte -> _______ -> segmented —–phil
Myeloblast; band
Granulocyte lineage: Myeloblast -> _______ -> myelocyte -> _______ -> band -> segmented —–phil
promyelocyte; metamyelocyte
IL-3 stimulates ______ production
basophil
IL-5 stimulates _______ production
eosinophil
In bone marrow, the ratio of granulocytic:erythroid precursors should be about ____.
3 to 1
In the erythroid lineage, the ability to replicate is lost at progession to the _______ stage.
Orthochromic normoblasts
In the granulcyte lineage, the last cell with replicative ability is the _______
myelocyte
In the granulocyte lineage, primary granules first appear in the ______ stage.
promyelocyte
In the granulocyte lineage, the largest cell is the _____
promyelocyte
In the megakaryocyte lineage, endoreduplication begins in the _____ stage.
promegakaryocyte
Male HCT
39-50%
Male Normal concentration of RBCs
4.75-6.1x10^12/L
Male normal HGB
14.3-18.1g/L
Megakaryocyte lineage: _______ -> _______ -> megakaryocyte -> platelet
megakaryoblast; promegakaryoctye
Men have _______ HGB and HCT than women
higher
Menstruating and pregnant women have _______ HGB and HCT
lower
Monocyte lineage: _______ -> _______ -> monocyte
monoblast; promonocyte
Normal Basophil %
0-2%
Normal Eosinophil %
0-6%
Normal Lymphocyte %
20-50
Normal MCH
27.5-35pg
Normal MCHC
32-36g/L
Normal MCV
80-100fL
Normal Monocyte %
2-11%
Normal Neutrophil %
40-72
Normal Platelet Count
150-400x10^9/L
Normal Reticulocyte %
0.4-1.7%
Normal WBC Count
4.0-11.1x10^9/L
Nuclear DNA remnants that appear as single, dense, blue dot can be described as_______.
Howell-Jolly Bodies
RI<1 with anemia indicates _______ production of RBCs
decreased
RI>2 with anemia indicates ______ production of RBCs
increased
The largest blood cell is a _______.
monocyte
This blood cell has a large kidney-shaped nucleus
monocyte
What is the function of erythropoietin? In what organ is it made?
Promote erythropoiesis; kidney
What is the function of thrombopoietin?
Promote production of megakaryocytes
When aggregated ribosomes are present in RBCs, they appear as _____.
basophilic stippling
