SLE Flashcards
The pathology of SLE?
In SLE the pathogenesis starts with the disruption of cell tolerance due to immune disregulation which triggers an innate immune system mediated interferon alpha up regulation. The activation of innate immune system is triggered by genetic and environmental factors.
What is the consequence of immune disregulation in SLE ?
The immune disregulation cause of defective apoptosis and defective clearance of apoptotic debries.
What is NETs or Neutrophil extracellular traps
?
It allows neutrophils to kill extracellular pathogens, while minimizing host cell damage.
What is the genetic signature of SLE?
Interferon alpha
How does interferon alpha drive immune response in SLE?
It activates T-cell lineages which activate B- cells by releasing IL-4, IL2/21 axis and B cell activating factors. This leads to the generation of antibodies and immune complexes.
What are the key sites of immune complex deposition in SLE?
Wherever the blood is filtered to form something such as glomerulus, capillaries, and synovium. This causes vasculitis, synovitis, and glomerulonephritis.
What type of hypersensitive reaction is SLE?
It is an immune complex mediated type 03 HSR polyserositis.
What are the key elements of immune disregulation in SLE?
*Defective clearance of apoptotic debries
* Defective Lymphocytic phagocytosis.
* Ineffective degradation of DNA containing NETs.
* Innate immune system activation
What is the most important genetic risk factor for SLE?
C1q deficiency followed by
C2 and C4 deficiency.
Which antibody is the sensitive marker for predicting the risk of lupus nephritis?
Anti CQ1 antibody.
Anti C1q antibody is seen what condition other than SLE
Hypocomplementimic urticarial vasculitis.
What is the histological marker of lupus nephritis?
Anti- C1q antibody.
