MSPA: Rheumatology- The spondylarthropathies and crystalline arthropathies Flashcards
What are the Major features of spondylarthropathies ?
- Inflammation of the axial joints especially sacroiliitis.
*Asymmetrical oligoarthritis - Dactylitis
- Enthesitis
- HLA-B27
What is Ankylosing Spondylitis?
It is a seronegative spondylarthropathy of unknown aetiology with strong correlation to HLAB-27 gene positivity. The inflammatory process is mediated by CD4+ and CD8+ T-Lymphocytes and macrophages inducing cytokine response through TNFα, TGF-β, and IL-17, which manifest as sacroiliitis and enthesitis along the spine causing the stiffness and bamboo spine appearance on X-Ray.
What is the epidemiology of ankylosing spondylitis ?
90% of the patients are HLAB-27 positive with 50% concordance rate. It is 3 times more common in men than in woman with a peak onset age range of 20-40.
What is the clinical presentation of ankylosing spondylitis ?
The hallmark is axial involvement which manifest as nocturnal back pain and stiffness that improves with exercise and not with rest. patients often have peripheral arthritis involving shoulder, hip , knee and ankle. The physical examination of the spine will often show kyphosis or kyphoscoliosis.
What are the systemic manifestations of ankylosing spondylitis ?
The patients often have constitutional symptoms, dactylitis, recurrent acute uveitis, IBD, and Achiliis tendinitis. The cardiovascular involvement may manifest as aortitis, Aortic regurgitation, and conduction abnormalities.
What are the Lab findings in Ankylosing spondylitis ?
Elevated ESR and CRP. All other markers of autoimmune or inflammatory diseases has to be negative ( seronegative).
What is the Tx of ankylosing spondylitis ?
- PT ,OT interventions and smoking cessation.
- NSAIDs
- steroid injections
- TNF alpha blockers such as Infliximab.
- IL-17 antagonists such as Secukinumab
What is the pathophysiology of reactive arthritis ?
It is a seronegative arthritis triggered often in HLA B-27 positive people by infectious antigens from GI pathogens such as Shigella, Salmonella etc. STIs due to C.trachomatis, and GAS.
What is the symptomatology of Reactive Arthritis?
In most cases the symptom onset is 2 to 3 weeks post infection and often presents as Reiter’s syndrome which consist of conjunctivitis, urethritis and joint inflammation. The patients may also present with cervicitis and pericarditis.
The joint involvement may manifest as a single large joint involvement, ankle, hip and small joints or polyarticular.
What are the laboratory evaluations in reactive arthritis ?
- Culture to rule out infections
- HLA-B27 +
- elevated ESR and CRP.
- RF and ACPA negativity.
What is the management of reactive arthritis ?
*Antibiotics to treat underlying infection.
* NSAIDs for pain control.
What is Psoriatic arthritis clinical presentation?
The dermal psoriatic lesions + asymmetric oligoarticular (<5 joints) involvement is the most common presentation in PA. Th rheumatoid pattern of polyarticular ( >5 joint) presentation and axial arthritis presentation may also be seen. However, the lab works will be negative for RA.
What is the management of Psoriatic arthritis ?
- NSAIDs
- DMARDs
- TNF antagonists
- IL-17 antagonists
- Surgery for hip and spine may be considered if medical management fails.
What is the pathophysiology of Gout ?
The under execration or over-production of uric acid causes the formation of MSU crystals, which gets deposited in and around the joints triggering humoral and cellular inflammatory process leading to acute gouty attacks.In chronic stage the disease causes MSU renal stone formation, interstitial nephritis, and most commonly tophi.
what are the causes of overproduction of uric acid ?
- Diet
- Genetics
- Tumour Lysis Syndrome
- Lymphoproliferative disorders
- Psoriasis
- Drugs: Warfarin, Cytotoxic agents