PAS hematology slides Flashcards
Bone marrow biopsy in ALL shows ?
> 20% Lymphoblasts
ALL remission rate ?
> 85%
Relapse rate in ALL ?
High -> SCT
Bone marrow biopsy in AML ?
> 20 % myeloblasts
Auer rods are seen in ?
AML ( it helps to deffrentiate it AML from ALL)
AML M3 ( ApML )
High risk of DIC : All trans retinoic acid and Arsenic trioxide.
AML type M5
High risk of Lukostasis ( leukopheresis)
Most common chronic lukemia in adults ?
CLL ( impaired maturation of Lymphoblasts to Lymphocytes).
CLL pathophysioloy ?
- delayed apoptosis of Lymphocytes.
*
What is the cause of infection in CLL ?
Hypogamaglobulinemia
Most common presenation of CLL?
Lymphadenopathy
What is the cause of hemolysis in CLL
Autoimmune hemolysis ( direct coomb test positive)
elevated LDH
Smudge cell is a Hallmark of
CLL
Bone marrow biopsy in CLL ?
Not required
What are the mutations significant for poor prognosis in CLL?
*ZAP-70+
*del(17p)
*del(11q)
Myeloid erythroid ratio in CML ?
3:1
Blasts in CML chronic vs blast phase
> 20 blast
<10 chronic
Lymphomas comprise what % of all malignancies ?
3
What are Hodgkin’s Cells ?
Mononuclear malignant B cells.
Immunological markers of Hodgkin’s Lymphoma ?
CD15 and CD13 positive.
Popcorn cells are seen in ?
Nodular Lymphocyte predominat Hodgkins Lymphoma.