Ewing's Sarcoma Flashcards

1
Q

What is the epidemiology of Ewing’s Sarcoma ?

A

It occurs mostly in males b/w the age of 5-30.

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2
Q

what is the common location of Ewing’s Sarcoma ?

A

In 50% of the time it occurs on the diaphysis of the long bones.

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3
Q

what are the bones that are most commonly affected in Ewing’s Sarcoma ?

A

femur, tibia, fibula, pelvis and the spine.

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4
Q

what are the X-ray findings in Ewing’s sarcoma ?

A

Moth eaten appearance as it is a primitive tumor. It also has onion skin and sunburst appearance due to periostial reaction.

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5
Q

What is Codman’s triangle ?

A

It is a small triangular shaped ectopic bone seen on the X-ray of the Ewing’s Sarcoma which is the result of ectopic bone formation that invades the soft tissue.

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6
Q

What is the histology of Ewing’s Sarcoma ?

A

Histologically Ewing’s Sarcoma consist of small, round blue cells with prominent nuceli and minimal cytoplasm and the cells may arrange in a pseudorosette fashion.

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7
Q

What is the key genetic mutation in Ewing’s sarcoma ?

A

It consist of a fushion protein called EWS/FLI-1 due to (11,22) translocation.

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8
Q

What is the clinical presentation of Ewing’s Sarcoma ?

A

It mimics infection as the patients presents with pain, fever, tenderness and a mass or Swelling.

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9
Q

What are the common blood findings in Ewing’s Sarcoma ?

A

Elevated ESR and CRP + eleavted WBC.

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10
Q

How to make the definite diagnosis of Ewing’s Sarcoma ?

A

Bone marrow biopsy to differentiate ES from other small round blue cell bone tumors such as Rhabdomyosarcoma.

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11
Q

What are the immuno-histochemical markers of Ewing’s Sarcoma ?

A

CD99+, MIC2+, Vimentin+ , and periodic acid schiff +

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12
Q

What is the Tx protocol for Ewing’s Sarcoma

A

It consist of chemotherpay followed by local control of tumor with wide resection and or radiation therapy.

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13
Q

When is chemotherapy used in Ewing Sarcoma ?

A

When it is high grade or is spread to other bones and lungs.

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14
Q
A
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