skin systmeic disease Flashcards
what can a punch biopsy look at?
neoplasia (histologyy)
immunofluorescence (auto antibodies)
cell cultures
what immunological things are seen in SLE
AMA
antiDSDNA
low complement
antiphospholipid
skin in SLE?
photodistributes rash
palpable purpura
SCLE
livedoreticularis
what is seen in cutaneous lupus?
SCLE
discoid lupus
scarring and ring like plaques
what ab is seen in neonatal lupus
ro
what should be done if neonatal lupus is suspectred
ECG
can lead to heart block
skin features of dermomyositis?
gottrons papules ragged cuticles shawl sign heliotriope rash photodistrubuted rash
what ab is associated with interstitual lung disease in dermo myositis
anti MDA5
investigations for dermomyositis
ANA CK biopsy LFT (ALT is up) EMG malignancy screening
what is associated with IgA vasculitis?
abdo pain
gi bleeding
glomerulonephritis
what is seen in anchor associated vasculitis
ulcerative rash
granulomatosis
nosebleeds
can be fatal
what is sarcoidiosis
granulomatous plaques on organs
what does the skin look like in sarcoidosis?
highly variable
what must be done for sarcoidosis diagnosis
exclude tb - culture/x rya
what is DRESS?
rash and systemic disorder with underlying mechanisms unknown
what is DRESS dianosis based on?
fever lymphadenopathy (2+ sites) atypical lymphocyres hypereosiniphilia organ involvement skin involvement (facial oedema)
what does the rash look like in dress
papules,
morbilliform eruption
widespread erythema
head oedema
how can you tell if a rash is caused by graft vs host?
face involvement
acral involvement
diarrhoea
what is th pathogenesis of graft vs host?
donor derived t lymphocye activity against antigens in immunosiuppression
investigations for priitus without rash?
fbc, ldh renal profile lft ferratin xray chest check fpr hiv etc
symptoms of scurvy??
spongy gums and bleeding
corkscrew hairs
ptetchiae,
follicular hyperkeratossis
what is the triad of symptoms seen in zinc deficiency?
dermatitis
diarrhoea
depression
what does b3 deficiency look like
dermatitis diarrhoea dementia death photodistributed erythema casals necklace
what is kwashiorkor?
protein deficiency
what causes carcinoid syndrome
5-ht secretion by metastatic cancers
symptoms of carcinoid?
diarrhoea
bronchospasm
hypotension
prodrome of SJSTEN?
flu like
what is the skin lesion like in SJSTEN?
lesions on trunk
artthroid
skin detachment like wet wallpaper
what is SJSTEN
cell mediated cytotoxic reaction against keratinocytes
how is SJSTEN assessed?
SCORTEN age, hr % epidermal attachment serum urea, glucose malignancy
how is SJSTEN classified?
sjs < 10%
sjs/ten 10-30
ten 30+
consequences of skin failure?
peripheral oedema tachycardia loss of fluid and protein disturbed thermoregulation sepsis
cutaneous signs of ckd?
anaemia
excoriations
calciphylaxis
half and half nails
cutaneous signs of chronic liver disease
excoriations
jaundice
terrys nails
clubbing
what is nectolosis liopoidica?
diabetes mellatus sign
plawues with red brown raised edge, yellow brown centre
what is eosiniphillic folliculitis a sign of?
hiv
what cutaneous disease are associated with ibd?
pyoderma gangrenosum
orofacial granulomatosis
celiac - dermatitis herpetiformis
what did you maybe get in summer 202-
hudradenititis suppuritiva
what is pyoderma gangrinosum
pustule on erythematous base which ulcerates
associated with IBD
