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GI cancers > skin systmeic disease > Flashcards

skin systmeic disease Flashcards

1
Q

what can a punch biopsy look at?

A

neoplasia (histologyy)
immunofluorescence (auto antibodies)
cell cultures

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2
Q

what immunological things are seen in SLE

A

AMA
antiDSDNA
low complement
antiphospholipid

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3
Q

skin in SLE?

A

photodistributes rash
palpable purpura
SCLE
livedoreticularis

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4
Q

what is seen in cutaneous lupus?

A

SCLE
discoid lupus

scarring and ring like plaques

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5
Q

what ab is seen in neonatal lupus

A

ro

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6
Q

what should be done if neonatal lupus is suspectred

A

ECG

can lead to heart block

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7
Q

skin features of dermomyositis?

A 
gottrons papules 
ragged cuticles 
shawl sign 
heliotriope rash 
photodistrubuted rash
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8
Q

what ab is associated with interstitual lung disease in dermo myositis

A

anti MDA5

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9
Q

investigations for dermomyositis

A 
ANA
CK
biopsy
LFT (ALT is up)
EMG 
malignancy screening
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10
Q

what is associated with IgA vasculitis?

A

abdo pain
gi bleeding
glomerulonephritis

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11
Q

what is seen in anchor associated vasculitis

A

ulcerative rash
granulomatosis
nosebleeds
can be fatal

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12
Q

what is sarcoidiosis

A

granulomatous plaques on organs

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13
Q

what does the skin look like in sarcoidosis?

A

highly variable

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14
Q

what must be done for sarcoidosis diagnosis

A

exclude tb - culture/x rya

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15
Q

what is DRESS?

A

rash and systemic disorder with underlying mechanisms unknown

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16
Q

what is DRESS dianosis based on?

A 
fever 
lymphadenopathy (2+ sites)
atypical lymphocyres
hypereosiniphilia
organ involvement
skin involvement (facial oedema)
17
Q

what does the rash look like in dress

A

papules,
morbilliform eruption
widespread erythema
head oedema

18
Q

how can you tell if a rash is caused by graft vs host?

A

face involvement
acral involvement
diarrhoea

19
Q

what is th pathogenesis of graft vs host?

A

donor derived t lymphocye activity against antigens in immunosiuppression

20
Q

investigations for priitus without rash?

A 
fbc, ldh 
renal profile 
lft 
ferratin 
xray chest 
check fpr hiv etc
21
Q

symptoms of scurvy??

A

spongy gums and bleeding
corkscrew hairs
ptetchiae,
follicular hyperkeratossis

22
Q

what is the triad of symptoms seen in zinc deficiency?

A

dermatitis
diarrhoea
depression

23
Q

what does b3 deficiency look like

A 
dermatitis 
diarrhoea 
dementia 
death
photodistributed erythema 
casals necklace
24
Q

what is kwashiorkor?

A

protein deficiency

25
Q

what causes carcinoid syndrome

A

5-ht secretion by metastatic cancers

26
Q

symptoms of carcinoid?

A

diarrhoea
bronchospasm
hypotension

27
Q

prodrome of SJSTEN?

A

flu like

28
Q

what is the skin lesion like in SJSTEN?

A

lesions on trunk
artthroid
skin detachment like wet wallpaper

29
Q

what is SJSTEN

A

cell mediated cytotoxic reaction against keratinocytes

30
Q

how is SJSTEN assessed?

A 
SCORTEN
age, 
hr
% epidermal attachment 
serum urea, glucose 
malignancy
31
Q

how is SJSTEN classified?

A

sjs < 10%
sjs/ten 10-30
ten 30+

32
Q

consequences of skin failure?

A 
peripheral oedema
tachycardia 
loss of fluid and protein 
disturbed thermoregulation 
sepsis
33
Q

cutaneous signs of ckd?

A

anaemia
excoriations
calciphylaxis
half and half nails

34
Q

cutaneous signs of chronic liver disease

A

excoriations
jaundice
terrys nails
clubbing

35
Q

what is nectolosis liopoidica?

A

diabetes mellatus sign

plawues with red brown raised edge, yellow brown centre

36
Q

what is eosiniphillic folliculitis a sign of?

A

hiv

37
Q

what cutaneous disease are associated with ibd?

A

pyoderma gangrenosum
orofacial granulomatosis

celiac - dermatitis herpetiformis

38
Q

what did you maybe get in summer 202-

A

hudradenititis suppuritiva

39
Q

what is pyoderma gangrinosum

A

pustule on erythematous base which ulcerates

associated with IBD

GI cancers (18 decks)

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