Skin Immunology Flashcards
What forms the keratin layer or stratum corneum
Formed by terminal differentiation of keratinocytes to corneocytes
Name the important structural proteins present in the keratin layer and epidermis
filaggrin
involucrin
keratin
What immunological properties do keratinocytes have
can be activated by UV light and sense pathogens
produce antimicrobial peptide
produce cytokines and chemokines
What are langerhans cells
antigen presenting cells
What characterises langerhans cells
Birbeck granule
What immunilogical role do langerhans cells have
dendritic
present antigens to T cells
help activate t cells
What type of t cell is mainly found in the epidermis
CD8
where are t cells produced
bone marrow
where do t cells mature
thymus
what is the role of cd4 helper cells
TH1 activate macrophages
Th2 help B cell make antibodies
‘helper cells’
What is the role of cd8
directly kill cells
What subsets of dendritic cells are found in the dermis
dermal - antigen presenting
plasmacytoid - produce IFN alpha
what is the function of dendritic cells
antigen presenting
produce cytokines and chemokines
what other types of cells are present in the dermis
macrophages
neutrophils - attracted to tissues by chemokines
Mast cells (IgE mediated)
What mediates type 1 hypersensitivity
IgE
What antibodies mediate type II and III hypersensivity
IgG
IgM
What is an arthis reaction
skin testing in type II hypersensitivity produces this reaction - it if slower than type I but faster than type II
What immune cells mediate type four
t cells
What are the two stages of allergic contact dermatitis
afferent or sensitising stage - exposure but no response yet
efferent ot elicitation phase
Give three examples of autoimmune causes of skin condition
psoriasis
vitiligo
SLE
List the immune cells in the epidermis
Langerhans
T cells
Keratinocytes (non immune(
List the immune cells in the dermis
dendritic
macrophages
T cells
NK killer cells
