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Dermatology > Skin Immunology > Flashcards

Skin Immunology Flashcards

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Dermatology Board Prep flashcards
1
Q

What forms the keratin layer or stratum corneum

A

Formed by terminal differentiation of keratinocytes to corneocytes

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2
Q

Name the important structural proteins present in the keratin layer and epidermis

A

filaggrin
involucrin
keratin

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3
Q

What immunological properties do keratinocytes have

A

can be activated by UV light and sense pathogens
produce antimicrobial peptide
produce cytokines and chemokines

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4
Q

What are langerhans cells

A

antigen presenting cells

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5
Q

What characterises langerhans cells

A

Birbeck granule

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6
Q

What immunilogical role do langerhans cells have

A

dendritic
present antigens to T cells
help activate t cells

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7
Q

What type of t cell is mainly found in the epidermis

A

CD8

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8
Q

where are t cells produced

A

bone marrow

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9
Q

where do t cells mature

A

thymus

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10
Q

what is the role of cd4 helper cells

A

TH1 activate macrophages
Th2 help B cell make antibodies
‘helper cells’

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11
Q

What is the role of cd8

A

directly kill cells

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12
Q

What subsets of dendritic cells are found in the dermis

A

dermal - antigen presenting

plasmacytoid - produce IFN alpha

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13
Q

what is the function of dendritic cells

A

antigen presenting

produce cytokines and chemokines

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14
Q

what other types of cells are present in the dermis

A

macrophages
neutrophils - attracted to tissues by chemokines
Mast cells (IgE mediated)

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15
Q

What mediates type 1 hypersensitivity

A

IgE

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16
Q

What antibodies mediate type II and III hypersensivity

A

IgG

IgM

17
Q

What is an arthis reaction

A

skin testing in type II hypersensitivity produces this reaction - it if slower than type I but faster than type II

18
Q

What immune cells mediate type four

A

t cells

19
Q

What are the two stages of allergic contact dermatitis

A

afferent or sensitising stage - exposure but no response yet

efferent ot elicitation phase

20
Q

Give three examples of autoimmune causes of skin condition

A

psoriasis
vitiligo
SLE

21
Q

List the immune cells in the epidermis

A

Langerhans
T cells
Keratinocytes (non immune(

22
Q

List the immune cells in the dermis

A

dendritic
macrophages
T cells
NK killer cells

Dermatology (22 decks)

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