Allergy Flashcards

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1
Q

What is hypersensitivity?

A

immune response that causes collateral damage to self

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2
Q

What is allergy

A

allergic reaction occur when a person’s immune system react to normally harmless substances in the environment

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3
Q

What is a type 1 hypersensitivity

A

immediate reaction after exposure.

consistent reaction with every exposure

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4
Q

What immune cells mediate type I reactions

A

IgE

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5
Q

What are the clinical presentations of a type one hypersensitivity reaction

A

urticarial
angio oedema
wheeze
anaphylaxis

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6
Q

How would you investigste a type one hypersensitivity reaction

A
History (most important)
Specific IgE (RAST)
Spin prick or prick prick testing
Challenge test
Serum mast cell tryptase level (during anaphylaxis)
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7
Q

when would a challenge test be indicated

A

only if skin prick testis negative

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8
Q

How much adrenaline is used in an adrenaline autoinjector for adults

A

300ug

150 for kids

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9
Q

Describe type four hypersensitivity

A

delayed
antigen specific
T cell mediated
onset of reaction is typically 24-48 hours after exposure

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10
Q

how would you investigate type four hypersensitivity

A

patch testing

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