Allergy

Question 1

What is hypersensitivity?

Answer 1

immune response that causes collateral damage to self

Question 2

What is allergy

Answer 2

allergic reaction occur when a person’s immune system react to normally harmless substances in the environment

Question 3

What is a type 1 hypersensitivity

Answer 3

immediate reaction after exposure.

consistent reaction with every exposure

Question 4

What immune cells mediate type I reactions

Answer 4

IgE

Question 5

What are the clinical presentations of a type one hypersensitivity reaction

Answer 5

urticarial
angio oedema
wheeze
anaphylaxis

Question 6

How would you investigste a type one hypersensitivity reaction

Answer 6

History (most important)
Specific IgE (RAST)
Spin prick or prick prick testing
Challenge test
Serum mast cell tryptase level (during anaphylaxis)

Question 7

when would a challenge test be indicated

Answer 7

only if skin prick testis negative

Question 8

How much adrenaline is used in an adrenaline autoinjector for adults

Answer 8

300ug

150 for kids

Question 9

Describe type four hypersensitivity

Answer 9

delayed
antigen specific
T cell mediated
onset of reaction is typically 24-48 hours after exposure

Question 10

how would you investigate type four hypersensitivity

Answer 10

patch testing