Allergy Flashcards
What is hypersensitivity?
immune response that causes collateral damage to self
What is allergy
allergic reaction occur when a person’s immune system react to normally harmless substances in the environment
What is a type 1 hypersensitivity
immediate reaction after exposure.
consistent reaction with every exposure
What immune cells mediate type I reactions
IgE
What are the clinical presentations of a type one hypersensitivity reaction
urticarial
angio oedema
wheeze
anaphylaxis
How would you investigste a type one hypersensitivity reaction
History (most important) Specific IgE (RAST) Spin prick or prick prick testing Challenge test Serum mast cell tryptase level (during anaphylaxis)
when would a challenge test be indicated
only if skin prick testis negative
How much adrenaline is used in an adrenaline autoinjector for adults
300ug
150 for kids
Describe type four hypersensitivity
delayed
antigen specific
T cell mediated
onset of reaction is typically 24-48 hours after exposure
how would you investigate type four hypersensitivity
patch testing