Skin & Breast Flashcards
what are the layers of the epidermis?
- stratum basale
- stratum spinosum
- stratum granulosum
- stratum lucidum
- stratum corneum
where are melanocytes found in the skin?
epidermis
- stratum basale
what is the function of melanocytes?
- synthesise melanin
- transfer melanin to surrounding keratinocytes in melanosomes
- absorb UV light
what stimulates melanocytes?
- MSH
- ACTH
where is most of the melanin found?
keratinocytes
what does skin colour depend on?
amount and type of melanin synthesised
what is normally the largest layer of the epidermis?
stratum spinosum
what is found in the stratum spinosum?
- keratinocytes
- langerhans cells
- merkel cells
what is the function of langerhans cells and are they seen readily on H&E?
- antigen recognition
- no
what is the function of merkel cells and are they seen readily on H&E?
- sensory
- no
describe the structure of the stratum granulosum
- flattened squames
what happens in the stratum granulosum?
- keratin formation
- epidermal keratinocytes mature
where is keratin formed?
stratum granulosum
where do epidermal keratinocytes mature?
stratum granulosum
which layer of the epidermis is visible on palms and soles?
stratum lucidum
describe the appearance of the stratum lucidum
thin and pale
what is the stratum corneum?
acellular plates of keratin (as dead keratinised squames)
where is the stratum corneum particularly thick and why?
- palms and soles
- helps to resist abrasive forces
what is the epidermal adnexae?-
downgrowths of the epidermis into underlying layers of the skin (dermis and subcutis)
what is found in the epidermal adnexae?
- hair follicles
- eccrine sweat glands
- apocrine sweat glands
where do hairs arise from?
germinative epithelium within hair bulb
what is responsible for the pigmentation of hair and where are they found?
melanocytes
- germinative epithelium within the hair bulb
where does hair lengthen?
within a root sheath composed of epidermis
what surrounds hair follicles?
collagenous follicle sheath
what muscule causes hairs to ‘stand on end’?
erector pili
where are the erector pili muscles found?
collagenous follicle sheath surrounding hair follicles