Sketchy Pharm: Prostaglandins, Prostacyclins, Bosentan, and PDE5 Inhibitors Flashcards

1
Q

What prostaglandin drug is used to treat erectile dysfunction?

A

Alprostadil (the erect dill pickle); this agent is a PGE1 analog (the skateboarder with the dill pickle skateboard loves EEExtreme sports); this works by dilating vasodilating arteries –can also be used to keep PDAs open (the bat he’s skating with is hitting the PDA pipe open)

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2
Q

Misoprostol is what kind of drug?

A

A PGE1 analog –think of the kid MISsing the ball with the bat in the Extreme sports section

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3
Q

What is misoprostol used for?

A

It stimulates protective mucus secretion in the GI tract and can be used to combat NSAID-related GI symptoms. Also, it can stimulate uterine contraction to promote labor or terminate pregnancy (the misoprostol boy knocked over the stack of uterus-shaped backpacks, spilling their contents).

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4
Q

Dinoprostone is what prostaglandin analog?

A

PGE2 (T-rex has Two arms)

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5
Q

What is dinoprostone used for?

A

To stimulate cervical dilation and uterine contraction –facilitating labor or abortion (kid with the dino helmet spilling the uterus backpack).

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6
Q

Carboprost mimics what molecule?

A

PGF-2alpha (the kid in the Footwear section with the CARdBOard box on his head)

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7
Q

Carboprost stimulates what?

A

Uterine contraction –useful in stimulating labor or preventing hemorrhage

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8
Q

Name two other PGF-2alpha drugs.

A

Latanoprost and travoprost (LA TAN sandals and TRAVel boots in the Footwear section)

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9
Q

Latanoprost and travoprost are used mainly for _____________.

A

glaucoma treatment (they increase aqueous humor outflow – not production! – as indicated by the eyeglass cleaner flowing over in excess from the overexcited kid)

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10
Q

Prostacyclins are mainly used to treat ____________.

A

pulmonary hypertension (the girl wielding fibrosed lung rackets in front of the PRO-CYCLer ball machine)

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11
Q

Why are prostacyclins used to pulmonary hypertension?

A

Because they are potent vasodilators (the dilated ball shooter)

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12
Q

What are two prostacyclin drugs commonly used to treat pulmonary hypertension?

A

Iloprost and epoprostenol

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13
Q

Prostacyclins must be given _____________.

A

intravenously

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14
Q

PDE5 inhibitors prevent the breakdown of ___________.

A

cGMP (the GruMP beneath the “don’t PHOSTEr DISinterest in sports)

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15
Q

PDE5 inhibitors end in _________.

A

-fill (such as sildenafil and tadanafil

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16
Q

Sildenafil and tadanafil are used to treat ____________.

A

pulmonary hypertension and erectile dysfunction (the rackets –again –and Babe Ruth’s erect bat)

17
Q

The pulmonary hypertension drug that requires monthly liver tests due to hepatotoxicity has what mechanism?

A

Endothelin inhibition (inducing vasodilation); this is bosentan (BOSs maN sTAN)