Sketchy Pharm: Maraviroc, Fusion Inhibitors, Integrase Inhibitors Flashcards
The gag gene encodes for proteins that are where in the virion?
Within the capsid (just like the gagged prisoners in the center of the ship around the sundial)
What proteins does gag encode?
It makes p24 and p7.
Think of the sundial having 24 hours 7 days a week.
Which HIV protein allows for entry into host cells?
gp120 (like the 120 ram)
What drug inhibits the entry of HIV virions?
Maraviroc (like the MARe rearing up in front of the poor defenseless squire)
Enfuvirtide inhibits a protein created by which gene?
Env (specifically, it inhibits the gp41 fusion protein)
Env genes have to be processed in ____________.
the endoplasmic reticulum
Think of the ER waves beneath the invading boat.
The pol gene encodes for ________________.
new enzymes: reverse transcriptase, protease, and integrase
Think of Paul the blacksmith making new enzymes.
Which protein does raltegravir inhibit?
It inhibits inTEGrase.
Think of the key deflector.
Integrase inhibitors can cause _______________.
myopathy (represented by the CK bucket of chicken)