Sketchy Pharm: Azoles Flashcards
List some of the azoles.
- Clotrimazole
- Ketoconazole
- Fluconazole
- Voriconazole
- Miconazole
- Itraconazole
Recall that fungal membranes utilize _____________.
ergosterol
In this scene, ergosterol is symbolized by the emerald wall around the city.
Azoles inhibit __________________.
the synthesis of ergosterol from lanosterol, which is accomplished by fungal CYP450 (like how the “LANe closed” sign is preventing the munchkins from bringing supplies to build the emerald wall; also, Dorothy’s house landed on a car with the CYP bumper)
Which azoles inhibit CYP450?
All of them do, but voriconazole does so more than others (which fits in this Sketch, because the vortex is what brought the house to crush the car)
What side effect is unique to voriconazole?
Blurry flashes of light and loss of color vision (like the blurred light patches in the tornado and the sepia background)
Voriconazole is one of the main treatments for ______________.
(two answers)
Aspergillosis (like the scarecrow coming out of the sepia scene) and Candida esophagitis (like the Canadian flag behind the tornado)
Fluconazole is often used for _______________.
three answers
- Vaginal candidiasis (snowball to crotch)
- Oropharyngeal candidiasis (easily scraped off snow covering ground)
- Cryptococcal meningitis (flying monkey on crypt)
- Esophageal candidiasis (esophagus gutters full of snow)
Which azole is often used for CNS infections?
Fluconazole
Think of the FLying monkeys wearing the meningitis helmets.
Which azole is best at treating dimorphic fungi infections?
Itraconazole (like the good wITch and her butterfly wings)
Another mnemonic: “ITraconazole for fungi with two ITerations”
Which azole is used topically?
Clotrimazole and miconazole
(Think of the TIN man –who represents TINea corporis –next to the lion getting a CLOse TRIM. Also, the lion is holding the cone close, saying “it’s My CONe!”)
_______________ is not often used systemically because of its potent CYP inhibition.
Ketoconazole (like the TIN man using the KEy to unlock the kidney lock)
Which enzyme is inhibited by ketoconazole?
17,20-desmolase (the enzyme that converts cholesterol to pregnenolone)
Ketoconazole is used systemically for _______________.
Cushing’s disease (represented by the moon face in the witch’s book)
What side effect is unique to ketoconazole?
Gynecomastia (because it prevents the synthesis of androgens)