Sketchy Pharm: NNRTIs Flashcards

1
Q

Name three NNRTIs.

A

Efavirenz, nevirapine, and delavirdine

Watch out: the third drug ends in the -dine suffix but is not an NRTI. Just remember Princess Delavir.

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2
Q

How are NRTIs different from NNRTIs?

A

NNRTIs do not need to be phosphorylated.

Think of the knight running away with the P scroll in hand –he’s not needed by the elves.

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3
Q

NNRTIs __________ inhibit reverse transcriptase.

A

allosterically (like the staff permanently jammed into the spell book)

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4
Q

What side effects do the NNRTIs have?

A

Jaundice and liver failure (evidenced by the yellow stag with the big liver spot)
Teratogenic (giant tarantula)
SJS (mask being pulled off of goblin)

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5
Q

Efavirenz specifically can cause ______________.

A

CNS changes such as hallucinations and nightmares

Think of the queen elf going crazy.

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6
Q

Nevirapine is a potent CYP ___________.

A

inducer (like the shiny new license plate on the sleek carriage)

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