Sketchy Pharm: NNRTIs Flashcards
Name three NNRTIs.
Efavirenz, nevirapine, and delavirdine
Watch out: the third drug ends in the -dine suffix but is not an NRTI. Just remember Princess Delavir.
How are NRTIs different from NNRTIs?
NNRTIs do not need to be phosphorylated.
Think of the knight running away with the P scroll in hand –he’s not needed by the elves.
NNRTIs __________ inhibit reverse transcriptase.
allosterically (like the staff permanently jammed into the spell book)
What side effects do the NNRTIs have?
Jaundice and liver failure (evidenced by the yellow stag with the big liver spot)
Teratogenic (giant tarantula)
SJS (mask being pulled off of goblin)
Efavirenz specifically can cause ______________.
CNS changes such as hallucinations and nightmares
Think of the queen elf going crazy.
Nevirapine is a potent CYP ___________.
inducer (like the shiny new license plate on the sleek carriage)