Sketchy Pharm: Glucocorticoids Flashcards

1
Q

Where (in the cell) are glucocorticoid receptors located?

A

In the cytosol

(Think of how the scepter – symbolic of the receptor –is initially outside the inner circle, but once it binds the moon it enters.)

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2
Q

The receptor-glucocorticoid complex binds to _____________.

A

promoter sequences for a number of genes; these sequences are called GREs: glucocorticoid response elements

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3
Q

How do glucocorticoids inhibit COX and LOX?

A

By inhibiting PLC A2 (like the cAtApult that is being hexed by the druid priest)

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4
Q

Glucocorticoids inhibit what transcription factor?

A

NF-kappa B, which normally promotes TNF-alpha and IL-2

Think of the iNFlamed KrossBow that is being stopped by the druid magic.

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5
Q

Inhibiting NF-kB stops what two cell types?

A

T and B cells (like the antibody archer and T-cell knight)

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6
Q

How do glucocorticoids cause neutrophilia?

A

They decrease migration and prevent adhesion.

Think of the neutro-first responders –with stretchers –who are unable to make it into the ring of stones.

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7
Q

Steroids cause decreased counts of which cell types?

A

T cells
B cells
Eosinophils

(Think of the falling antibody archer, T-cell knight, and eo-slingshot boy.)

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8
Q

Steroids can cause insulin _____________.

A

resistance (like the knight who can’t enter the ring over the “welcome inside” mat)

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9
Q

How does Sketchy illustrate the contrary effects that corticosteroids have on blood sugar?

A

Sketchy shows how cortisol raises gluconeogenesis by the druid that is taking candy from a liver-shaped bag and putting it on the pedestal, and they also show how glycogen stores are increased by the liver jar filled with candy.

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10
Q

Exogenous corticosteroid use does what to the adrenals?

A

Causes atrophy

Think of the druid with the shriveled hat who’s fallen over due to adrenal insufficiency after stopping steroid use.

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11
Q

What effect does glucocorticoid have on protein and fat?

A

It promotes proteolysis and lipolysis (like the meat and doughnuts falling off the table)

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12
Q

Corticosteroids can cause reactivation of latent infections, most worryingly _____________.

A

TB; recurrent TB usually affects the upper lobes, just like how the Sketchy TB cactus only has the upper portions affected

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13
Q

Adrenal insufficiency leads to ________-glycemia.

A

hypo (represented by the falling man with the spilling candy)

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