Sketchy Pharm: Bupropion, Mirtazipine, and Trazodone COPY Flashcards

1
Q

You might administer what NET- and DAT-reuptake inhibiting agent to someone trying to quit smoking?

A

Bupropion (NET DAT Ball, PRO)

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2
Q

Why does bupropion reduce the urge to smoke?

A

It’s not clear.

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3
Q

What is a major side effect of bupropion?

A

Seizures (think of the basketball player shaking) – do not give bupropion to anyone with a history of seizures, anorexia, or bulimia (both of the last two have lower seizure thresholds).

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4
Q

Although bupropion (Wellbutrin) is not first-line for unipolar depression in a non-smoker, it has two advantages over other antidepressants. What are they?

A

It is not associated with sexual dysfunction (think of the kissing couple), and it does not lead to weight gain

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5
Q

How does mirtazipine work?

A

It decreases alpha-2 input on presynaptic neurons, thereby leading to increased catecholamine release; additionally, it has mild 5HT-2 and 5HT-3 receptor antagonist properties.

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6
Q

What side effects are associated with mirtazipine?

A

H1 histamine antagonist, sleepiness, weight gain (overweight, sleepy fan in the box with the chef swatting a bee) –like bupropion, though, it does not lead to sexual dysfunction.

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7
Q

Trazodone is a __________ modulator.

A

serotonin (guy playing the happy face drum next to the trombone player)

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8
Q

What side effect does trazodone have?

A

Because it antagonizes alpha-1 receptors, it leads to vasodilation –this can lead to hypotension or priapism (erection in the absence of sexual arousal); think of the nickname trazobone. Also, sexual dysfunction and serotonin syndrome (band member and spilled happy faces).

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9
Q

Although trazodone started out as an anti-depressant, it is now mostly used for ____________.

A

sedating those with insomnia (because it is an H1 antagonist)

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