Sketchy Pharm: Bupropion, Mirtazipine, and Trazodone COPY Flashcards
You might administer what NET- and DAT-reuptake inhibiting agent to someone trying to quit smoking?
Bupropion (NET DAT Ball, PRO)
Why does bupropion reduce the urge to smoke?
It’s not clear.
What is a major side effect of bupropion?
Seizures (think of the basketball player shaking) – do not give bupropion to anyone with a history of seizures, anorexia, or bulimia (both of the last two have lower seizure thresholds).
Although bupropion (Wellbutrin) is not first-line for unipolar depression in a non-smoker, it has two advantages over other antidepressants. What are they?
It is not associated with sexual dysfunction (think of the kissing couple), and it does not lead to weight gain
How does mirtazipine work?
It decreases alpha-2 input on presynaptic neurons, thereby leading to increased catecholamine release; additionally, it has mild 5HT-2 and 5HT-3 receptor antagonist properties.
What side effects are associated with mirtazipine?
H1 histamine antagonist, sleepiness, weight gain (overweight, sleepy fan in the box with the chef swatting a bee) –like bupropion, though, it does not lead to sexual dysfunction.
Trazodone is a __________ modulator.
serotonin (guy playing the happy face drum next to the trombone player)
What side effect does trazodone have?
Because it antagonizes alpha-1 receptors, it leads to vasodilation –this can lead to hypotension or priapism (erection in the absence of sexual arousal); think of the nickname trazobone. Also, sexual dysfunction and serotonin syndrome (band member and spilled happy faces).
Although trazodone started out as an anti-depressant, it is now mostly used for ____________.
sedating those with insomnia (because it is an H1 antagonist)