Skeletal System Pathologies Flashcards

1
Q

Caused by diminished proliferation of cartilage in the growth plate

Individuals have short limbs, which contrast with an average length of trunk (axial skeleton)

A

Achondroplasia (dwarfism)

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2
Q

Occurs at junction of spine segments
Congenital disorder
Usually occurs in lumbar/sacral junction
*can occur at any junction - c/t, t/l

A

Transitional vertebrae

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3
Q

-Posterior defect of the spinal canal, resulting from failure of the posterior elements to fuse properly
-large defects are associated with spinal cord abnormalities, may lead to a variety of muscular abnormalities and lack of bladder/bowl control

A

Spina Bifida
*in many cases, slight dimpling of the skin or a tuft of hair over the vertebral defect indicates the site of lesion

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4
Q

Spina Bifida

Germination of the meninges caused by large defects in lumbar or cervical spine

A

Meningocele

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5
Q

What are some other associated malformations of Spina Bifida meningocele?

A

Clubfoot, gait disturbances, bladder inconsistence

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6
Q

Spina Bifida

Germination of the meninges and a portion of the spinal cord or nerve roots

A

Myelomeningocele

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7
Q

What is an associated symptom of myelomeningocele Spina Bifida?

A

Associated neurological deficits at and below the site of protrusion

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8
Q

Spina Bifida

Mild insignificant form
Splitting of the bony neural canal at the L5 or S1 level
Failure of the posterior elements to fuse

A

Spina Bifida Occulta

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9
Q

A genetic disorder characterized by fragile, easily breakable bones
AKA - OI, brittle bone disease, fragile bone disease

A

Osteogenesis Imperfecta
Other symptoms include:
-muscle weakness
-hearing loss
-joint hyperlaxity
-chronic bone pain
-curved bones
-respiratory complications
-scoliosis
-brittle teeth (dentinogenesis imperfecta)
Blue sclera (eyes)

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10
Q

A rare hereditary bone dysplasia in which failure of the restorative mechanism of calcified cartilage interferes with the normal replacement by mature bone

Prevents bone marrow from forming so that the bones become very brittle and stress fractures can occur

A

Osteopetrosis
“Marble bones”
*may cause anemia as a result of lack of blood producing bone marrow

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11
Q

Acetabulum is too shallow and the femur may partially or totally dislocate, tendons and ligaments responsible for proper alignment are affected

Affects pediatric patients

A

Developmental dysplasia of the hip
DDH
AKA congenital hip dysplasia

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12
Q

A twisting of the spine;curvature in the lateral perspective, somewhat like an S curve

A

Scoliosis

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13
Q

What are the 4 types of scoliosis?

A

Idiopathic - cause unknown

Functional - caused by problem outside the spine

Neuromuscular - occurs when the vertebra fails to form completely or fails to separate appropriately

Degenerative - adult type scoliosis, caused by arthritis

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14
Q

Auto immune disease, non infectious
Crippling deformity of joints

Begins as inflammation of synovial membrane of joints
-excessive amounts of exudate are excreted into the synovial fluid (thickened fluid)

A

Rheumatoid arthritis RA

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15
Q

Chronic inflammatory rheumatic disease
Causes the vertebrae to fuse together (bamboo spine)

Can also cause excess growth of vertebral projections called bony protuberances causing pain and limited mobility

A

Ankylosing Spondylitis (AS)

Ankylosing = fusion
Spondylitis = spine and inflammation

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16
Q

What other parts f the body can be affected by Ankylosing Spondylitis?

A

Inflammation and stiffness in:
-hip, shoulder, knees
-ribs
-heels
-hand/feet joints

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17
Q

A generalized disorder characterized by loss of joint cartilage and reactive new bone formation
Normal part of aging
*commonly affects weight bearing joints

A

Osteoarthritis (OA)
AKA - DJD

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18
Q

An inflammation of the bone and bone marrow that can be caused by various organisms, predominantly bacteria
Most commonly caused by staphylococci and streptococci bacteria

A

Osteomyelitis

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19
Q

Where might the infection spread to the bone from in osteomyelitis?

A

In osteomyelitis, infection may spread to the bone from:
-nearby infected structures
-penetrating trauma or surgery
-bloodstream
Weakens parts of the bone are more susceptible

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20
Q

What are some common risk factors for osteomyelitis?

A

-injury or trauma
-uncontrolled infections elsewhere in the body
-post surgery
-immune system conditions
-IV drug use
-circulation disorders
-diabetes

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21
Q

Commonly seen in the femoral head
Caused by loss of blood supply
(Can result from thrombosis, vasculitis, disease of surrounding bone, single or repeated episodes of trauma)
*bone is starting to die

A

Ischemic Necrosis

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22
Q

A hormonal disorder that develops when your pituitary gland produces excessive growth hormone is on skeletal mature patients
*most commonly from a pituitary adenoma (benign tumor of pituitary gland)

A

Acromegaly
(Gigantism)

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23
Q

What are common manifestations of acromegaly?

A

Enlargement of hands, feet’s, nose, tongue, lips, ears

General thickening of the skin

Internal organs overgrowth

Vocal cords, resulting in a characteristic thick, deep voice and slowing speech (overgrowth)

Excessive hair growth and sweating

Vertebral fractures

24
Q

A deficiency of bone matrix in which mass of bone per unit volume is decreased in amount but normal in composition (bone density)

A

Osteoporosis
*bond is constantly changing and normally exists between the amount of old bone being removed (an osteoclastic process) and the amount of new bone replacement (an osteoblastic process)

25
Q

T/F
Osteoporosis is a major cause of hip, spine, wrist fractures

26
Q

T/F
Osteoporosis is difficult to diagnose without diagnostic imaging

A

True

Other manifestations might be, back pain from damaged vertebrae, bone tissue fractures easily

27
Q

Lower than normal bone mass, skeletal demineralization
Can be generalized or regional

*defined as a BMD T-score lower than -1.0 but higher than -2.5

A

Osteopenia

See slide 61

28
Q

A metabolic disorder where purine (a nucleic acid) is not metabolized

This increases uric acid in the blood and deposits uric acid crystal in the joints, cartilage and kidneys

29
Q

Destruction of bone followed by a repetitive process, results in weakened, deformed, and thickened bony structures that tend to fracture easily
Affects particularly the pelvis, femurs, skull, tibias, clavicles and ribs

A

Paget’s disease (osteitis deformans)

30
Q

What are the two different phases of Paget’s disease?

A

Destructive - predominates initially, more frequently a combination of destruction and repair in the pelvis and weight bearing bones
Repetitive - may begin early and may be prominent feature often invoking multiple bobes

31
Q

Bone softening due to inadequate intake of, or failure of absorption of calcium, phosphorus and vitamin D

A

Osteomalcia
“Rickets” in children

32
Q

What patients may osteomalacia occur most commonly in?

A

-Those who live in climates with little sunlight exposure
-work or stay inside during daylight hours
-lactose intolerant
-vegetarians

33
Q

What is the most widely accepted method of determining skeletal bone age?

A

Radiographic atlas of Greulich and Pyle

34
Q

What areas are most commonly affected by advanced or delayed bone age?

A

Hand, wrist, knee

35
Q

What are the key points for bone tumor classification?

A

Site of lesion, border of lesion, periosteal reaction
Smaller = nodule
Larger = mass

36
Q

Also called “unicameral” bone cyst
Benign, fluid filled cyst surrounded by a fibrous tissue wall
Asymptomatic

A

Simple bone cyst

Usually found in prox humerus/femur

37
Q

What are the Radiographic signs of a cyst?

A

Darker area of bone

Circular, uniform

38
Q

Benign bone cyst, like simple bone cyst
Rather than being a true neoplasm or cyst, consists of numerous blood filled arteriovenous communications thought to be caused by trauma

A

Aneurysmal bone cyst

39
Q

An overgrowth of cartilage and bone that happens near the growth plate
Most often affects long bones in leg, pelvis, scapula

A

Osteochondroma

Pediatric pathology

40
Q

What is the most common non cancerous bone growth?

A

Osteochondroma

41
Q

Highly malignant tumors that arise from connective tissue, spread rapidly
Generally occur in the end of long bone (metaphysis)
Commonly occurs in patients 10-25 years old

A

Osteosarcoms

42
Q

What are common causes and symptoms of osteosarcoma?

A

Causes:
-oncogenes - turned on
-tumor suppressor genes - turned off
-inherited gene mutations of acquired gene mutations
Symptoms:
-pain, swelling, fever, lump, mass, bone fracture with no injury

43
Q

What pathology is the sunburst pattern and Codmans triangle seen in?

A

Osteosarcoma

44
Q

A primary malignant tumor arising in the bone marrow of long bones, children/young adults are affected

A

Ewings Sarcoma
-local pain
-malaise
-sick
-fever

45
Q

Widespread malignancy of plasma cells that may be associated with bone destruction, bone marrow failure, hypercalcimia, renal failure, recurrent infections
Primary bone tumor attacks the intramedullary canal of the diaphysis

A

Multiple myeloma
(Punched out lesions)

46
Q

A joint condition where bond underneath cartilage of a joint dies due to lack of blood flow
The bone and cartilage of the joint break loose, causing pain and possibly hindering joint motion

A

Osteochondritis Dissecans
*common in children/adolescents
*most common in knees, but can occur in elbows, ankles…

47
Q

Degeneration of the spine
Can occur in C, T, or L vertebrae

Often used to describe OA of the spine

A

Spondylosis

48
Q

Stress fracture in the lumbar vertebrae (most commonly L5 or L4)
Fractured in the pars interarticularis without displacement

A

Spondylolysis

*caused by activities that include repeated back bending, weight bearing, rotation

49
Q

A progression of spondylolysis

When stress fracture weakens the bone, it can cause the vertebrae to slip anterior over the vertebrae below
**fracture of the pars interarticularis with displacement

A

Spondylolisthesis

50
Q

A twisted neck where the head is tipped to one side, and the chin to the other
Usually results from the unilateral fibrosis and shortening of the sternocleidomastoid muscle
*can be acquired of congenital

A

Torticollis

51
Q

Anterior concave in the curvature of the thoracic spine, sacrum, coccyx, as viewed from the side
Caused by:
-fractures
-osteoporosis
-disk degeneration
-birth defects
-scoliosis
-cancer/cancer treatment

52
Q

Anterior convex in the curvature of the lumbar and cervical spine as viewed from the side
Caused by:
-acondroplasia
-discitis
-kyphosis
-obesity
-osteoporosis
-spondylolisthesis

53
Q

Refers to physically induced injuries in young children caused by parents or guardians

A

Non accidental trauma

54
Q

A disease that affects children between 4-10
4x more common in males than females
Idiopathic avascular necrosis of the femoral head
Involves the destruction of the femoral head and sometimes acetabulum

A

Legg-Calve-Perthes disease

55
Q

Common cause of knee pain in growing adolescents
Inflammation of tibial tuberosity

A

Osgood Schlatter disease