skeletal system development Flashcards

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0
Q

what does paraxial mesoderm form?

A

somites (occipital)

somitomeres (head)

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1
Q

what embryological layers make the skeletal system?

A

paraxial mesoderm
lateral plate mesoderm
neural crest cells

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2
Q

what does lateral plate mesoderm form?

A

pelvic and shoulder girdles

bones of the limbs

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3
Q

what do the neural crest cells form?

A

in the head, the bones of the face and skull

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4
Q

what specifically forms the neurocranium (protective part around the brain)?

A

neural crest cells and paraxial mesoderm

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5
Q

the bones of the chondrocranium in front of the rostral limit of the notochord are derived from what?

A

neural crest cells

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6
Q

bones of the chondrocranium in back of the rostal limit of the notochord are derived from what?

A

occipital sclerotomes (paraxial mesoderm)

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7
Q

viscerocranium forms what?

A

bones of the face

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8
Q

the 1st arch dorsal portion (maxillary process) gives rise to what?

A

maxilla, zygomatic bone, temporal bone

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9
Q

1st arch ventral portion (mandibular process) gives rise to what?

A

meckel cartilage, malleus, incus, and stapes

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10
Q

what are sutures derived from?

A

neural crest and paraxial mesoderm

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11
Q

what are limb buds derived from?

A

core of lateral plate mesoderm covered by ectoderm

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12
Q

what is the apical ectodermal ridge?

A

a band of mesoderm that develops at the distal end of limb bud to keep the distal mesoderm from differentiating

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13
Q

how do fingers and toes form?

A

by cell death in the AER that separates it into 5 parts then segments continue to grow

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14
Q

what happens in terms of rotation around 7 weeks?

A

the limbs rotate in opposite directions (lower medially and upper laterally)

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15
Q

what factors insure that digits appear in the correct order?

A

ZPA produces retinoic acid which induces SHH

16
Q

which growth factors are needed for proximodistal patterning (AER maintaining )?

A

FGF-10 initiates outgrowth
BMF’s induce AER and radical fringe + engrailed keep it there
FGF-4 + FGF-8 maintain everything

17
Q

how do we get things to be dorsal and ventral?

A

Dorsal: WNT7a induces LMX1= dorsal cells
Ventral: BMPs found in ventral cells which represses WNT7a

18
Q

the notochord becomes what adult structure?

A

the nucleus pulposus

19
Q

what does the the sternum develop from?

A

somatic mesoderm in the ventral body wall