SJS & TEN

Question 1

what are SJS and TEN

Answer 1

spectrum of same disease
disproportionate immune response to epidermal necrosis leading to blistering and shedding of the epidermis

SJS <10%
TEN>10%

Question 2

which medications can cause SJS and TEN

Answer 2

antibiotics (Beta lactams)
anti-epileptics
allopurinol
NSAIDs

Question 3

which infections can cause SJS and TENs

Answer 3

HIV (inc risk 100x)
herpes simplex
mycoplasma pneumonia
cytomegalovirus

Question 4

presentation of TEN

Answer 4

flu like symptoms for several days
tender red/purple rash starting on the trunk and rapidly spreading
blisters, which merge and lead to detachment leaving oozing red dermis visible
mucosal involvement

symptoms peak within 4 days

Question 5

what can mucosal involvement include in SJS/TEN

Answer 5

eyes
mouth
genitals
urinary tract
GI
upper respiratory tract

Question 6

complications which can arise from SJS/TEN

Answer 6

secondary infection - cellulitis, sepsis
permenant skin damage
visual complications

Question 7

management of SJS/TEN

Answer 7

admission under specialist for steriod/ immunoglobulins/ immunosuppression

supportive care: nutritional, analgesia, opthalmology