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4: neurology and special senses > SJS & TEN > Flashcards

SJS & TEN Flashcards

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1
Q

what are SJS and TEN

A

spectrum of same disease
disproportionate immune response to epidermal necrosis leading to blistering and shedding of the epidermis

SJS <10%
TEN>10%

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2
Q

which medications can cause SJS and TEN

A

antibiotics (Beta lactams)
anti-epileptics
allopurinol
NSAIDs

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3
Q

which infections can cause SJS and TENs

A

HIV (inc risk 100x)
herpes simplex
mycoplasma pneumonia
cytomegalovirus

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4
Q

presentation of TEN

A

flu like symptoms for several days
tender red/purple rash starting on the trunk and rapidly spreading
blisters, which merge and lead to detachment leaving oozing red dermis visible
mucosal involvement

symptoms peak within 4 days

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5
Q

what can mucosal involvement include in SJS/TEN

A

eyes
mouth
genitals
urinary tract
GI
upper respiratory tract

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6
Q

complications which can arise from SJS/TEN

A

secondary infection - cellulitis, sepsis
permenant skin damage
visual complications

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7
Q

management of SJS/TEN

A

admission under specialist for steriod/ immunoglobulins/ immunosuppression

supportive care: nutritional, analgesia, opthalmology

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4: neurology and special senses (26 decks)

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