Signs & Symptoms Flashcards
what is jaundice?
yellowing of the skin
what is the cause of jaundice
high levels of bilirubin in blood which happens due to an obstruction of the biliary tree
what is the pathophysiology of jaundice
bile backs up into liver so overspill into blood
3 corner stones of presenting symptoms of excess bile in blood…
jaundice, pale stools, dark urine, itch
investigations for jaundice
USS, CT
how is jaundice classified
in terms of site and type
site: pre-hepatic, hepatic, post-hepatic
type: conjugated and un-conjugate
what does pre-hepatic jaundice mean?
too much haem to break down (heamolysis of any cause)
what does hepatic jaundice mean?
acute liver failure, alcoholic hepatitis, cirrhosis, bile duct loss
what is post-hepatic jaundice
congenital biliary atresia, gallstones, strictures, tumours
main indicator of pre-hepatic jaundice?
reduced haemoglobin
main marker of hepatic jaundice
raised bilirubin, AST/ALT
what is the main marker of post-hepatic jaundice
raised bilirubin, ALP ad slightly raised AST/ALT
what is the definition of diarrhoea?
> 3 unformed stools per day
complications of diarrhoea?
metabolic acidosis, hypokalaemia, dehydration
tx for diarrhoea
rehydration therapy and antidiarrhoeal agents
what is malabsorption
defective mucosal absorption
causes of malabsorption
crohn’s, post-infectious, biliary obstruction, cirrhosis
types of malabsorption?
fats, proteins, vitamins, minerals
some signs of malabsorption?
flatulence, diarrhoea, abdominal pain, steatorrhea, distension, fever
ix for lactose malabsorption
lactose breath hydrogen test, oral lactose intolerant test